prikaz prve stranice dokumenta Prognostic significance of bone morphogenetic protein 6 (BMP6) expression, clinical and pathological factors in clinically node-negative oral squamous cell carcinoma (OSCC)
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Scientific paper - Original scientific paper
Prognostic significance of bone morphogenetic protein 6 (BMP6) expression, clinical and pathological factors in clinically node-negative oral squamous cell carcinoma (OSCC)
Journal of Cranio-Maxillofacial Surgery, 47 (2019), 1; 80-86. https://doi.org/10.1016/j.jcms.2018.10.003
Suton, Petar; Bolanča, Ante; Grgurević, Lovorka; Erjavec, Igor; Nikles, Iva; Muller, Danko; Manojlović, Spomenka; Vukičević, Slobodan; Petrovečki, Mladen; Dokuzović, Stjepan; Lukšić, Ivica

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Suton, P., Bolanča, A., Grgurević, L., Erjavec, I., Nikles, I., Muller, D. ... Lukšić, I. (2019). Prognostic significance of bone morphogenetic protein 6 (BMP6) expression, clinical and pathological factors in clinically node-negative oral squamous cell carcinoma (OSCC). Journal of Cranio-Maxillofacial Surgery, 47. (1), 80-86. doi: 10.1016/j.jcms.2018.10.003

Suton, Petar, et al. "Prognostic significance of bone morphogenetic protein 6 (BMP6) expression, clinical and pathological factors in clinically node-negative oral squamous cell carcinoma (OSCC)." Journal of Cranio-Maxillofacial Surgery, vol. 47, no. 1, 2019, pp. 80-86. https://doi.org/10.1016/j.jcms.2018.10.003

Suton, Petar, Ante Bolanča, Lovorka Grgurević, Igor Erjavec, Iva Nikles, Danko Muller, Spomenka Manojlović, et al. "Prognostic significance of bone morphogenetic protein 6 (BMP6) expression, clinical and pathological factors in clinically node-negative oral squamous cell carcinoma (OSCC)." Journal of Cranio-Maxillofacial Surgery 47, no. 1 (2019): 80-86. https://doi.org/10.1016/j.jcms.2018.10.003

Suton, P., et al. (2019) 'Prognostic significance of bone morphogenetic protein 6 (BMP6) expression, clinical and pathological factors in clinically node-negative oral squamous cell carcinoma (OSCC)', Journal of Cranio-Maxillofacial Surgery, 47(1), pp. 80-86. doi: 10.1016/j.jcms.2018.10.003

Suton P, Bolanča A, Grgurević L, Erjavec I, Nikles I, Muller D, and sur.. Prognostic significance of bone morphogenetic protein 6 (BMP6) expression, clinical and pathological factors in clinically node-negative oral squamous cell carcinoma (OSCC). Journal of Cranio-Maxillofacial Surgery [Internet]. 2019 January [cited 2024 April 11];47(1):80-86. doi: 10.1016/j.jcms.2018.10.003

P. Suton, et al., "Prognostic significance of bone morphogenetic protein 6 (BMP6) expression, clinical and pathological factors in clinically node-negative oral squamous cell carcinoma (OSCC)", Journal of Cranio-Maxillofacial Surgery, vol. 47, no. 1, pp. 80-86, January 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:792561. [Accessed: 11 April 2024]

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Title (english)Prognostic significance of bone morphogenetic protein 6 (BMP6) expression, clinical and pathological factors in clinically node-negative oral squamous cell carcinoma (OSCC)
AuthorPetar Suton
AuthorAnte Bolanča
AuthorLovorka Grgurević
AuthorIgor Erjavec
AuthorIva Nikles
AuthorDanko Muller
AuthorSpomenka Manojlović
AuthorSlobodan Vukičević
AuthorMladen Petrovečki
AuthorStjepan Dokuzović
AuthorIvica Lukšić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Maxillofacial Surgery and Dentistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Abstract (english)
Bone morphogenetic protein 6 (BMP6) has unique properties regarding structure and function in supporting bone formation during development and adult life. Despite its known role in various malignant tumors, the prognostic significance of BMP6 expression in oral squamous cell carcinoma (OSCC) remains unknown. The aim of the study was to investigate immunohistochemical expression of BMP6 in OSCC in correlation with clinical and pathological parameters, disease recurrence and survival. In addition, we investigated other parameters in order to identify prognosticators of neck metastases and final outcome. The study included 120 patients with clinically T1-3N0 OSCC who were primarily surgically treated between 2003 and 2008. There were 99 (82.5%) male and 21 (17.5%) female patients. The five-year disease-specific survival for the whole cohort was 79.7%. Tumors smaller than 2 cm in diameter showed higher incidence of strong BMP6 expression. No statistical correlation was observed between other clinico-pathological factors and BMP6 expression. Expression of BMP6 was not associated with disease recurrence and survival. BMP6 may not serve as prognosticator of final outcome or recurrence in clinically node-negative OSCC subjects. In multivariate analysis predictors of poorer survival were positive surgical margin, moderate tumor cell differentiation and pathological involvement of levels IV and/or V.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleJournal of Cranio-Maxillofacial Surgery
Numberingvol. 47, no. 1, pp. 80-86
p-ISSN1010-5182
e-ISSN1878-4119
DOIhttps://doi.org/10.1016/j.jcms.2018.10.003
URN:NBNurn:nbn:hr:105:792561
Publication2019-01
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S1010518218308485
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-02-08 11:09:12