Elektrokardiografske promjene kod sustavnog onkološkog liječenja

master's thesis

• Title (english): Electrocardiographic changes in systemic cancer treatment
• Author: Matko Spicijarić
• Mentor: Diana Delić-Brkljačić (mentor)
• Committee member: Nikola Bulj (predsjednik povjerenstva)
• Committee member: Martina Lovrić Benčić (član povjerenstva)
• Committee member: Diana Delić-Brkljačić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2020-07-17, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Oncology

Abstract

Zbog današnje sveprisutnosti onkoloških bolesti, drugog po redu uzroka smrtnosti u Hrvatskoj, ali i razvijenijim zemljama svijeta, raste i upotreba sustavne onkološke terapije. Iako u odnosu s kirurškim i radioterapijskim pristupom djeluje mnogo benignije, ona također izaziva brojne nuspojave. Jedna od njih je i kardiotoksičnost. Kardiotoksičnost možda nije toliko česta nuspojava, ali njezine posljedice mogu biti vrlo teške. Jedan od oblika vrednovanja kardiotoksičnosti jest i mjerenje električne aktivnosti srca putem EKG-a. Njegove promjene najčešće su zabilježene prilikom primjene klasičnih kemoterapeutika kao što su antraciklini, alkilirajući citostatici te spojevi platine, a nešto rjeđe bile su kod primjene pametnih lijekova. Najčešće promjene zabilježene u većine lijekova bile su aritmije različitog oblika. Također, veoma prisutno bilo je i produljenje QTc intervala, a nešto rjeđe su se pojavljivale promjene ST segmenta, T i P vala i smanjena voltaža QRS kompleksa. Kardiotoksičnost se pokazala ovisnom o dozi i trajanju primjene pojedinog lijeka, ali svi su imali otprilike jednak zaključak da treba redovito pratiti kardiološke pokazatelje te pri bilo kakvoj promjeni utvrditi uzrok i trajno ili privremeno prekinuti terapiju.

Abstract (english)

Due to the current ubiquity of oncological diseases, the second leading cause of death in Croatia, but also in most developed countries, the use of systemic oncological therapy is growing. Although it seems much more benign compared to the surgical and radiotherapy approach, it also causes a number of side effects. One of them is cardiotoxicity. Cardiotoxicity may not be such a common side effect, but its consequences can be very severe. One form of cardiotoxicity evaluation is the measurement of the electrical heart activity via an ECG. Its changes were most often observed with the use of classical chemotherapeutics such as antracyclins, alkylating cytostatics and platinum compounds and somewhat less frequently with the use of smart drugs. The most common changes observed in most drugs were arrhythmias of various forms. Also, the prolongation of the QTc interval was very present, and changes in the ST segment, T and P waves and decreased voltage of the QRS complex occurred somewhat less frequently. Cardiotoxicity has been shown to be dose-and duration-dependent, but all have roughly the same conclusion that cardiac parameters should be monitored regularly and in case of any change, the cause must be determined and the therapy permanently or temporarily discontinued.

• Keywords: sustavna onkološka terapija; promjene EKG-a; kardiotoksičnost
• Keywords (english): systemic cancer treatment; ECG changes; cardiotoxicity
• Language: croatian
• URN:NBN: urn:nbn:hr:105:770369
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-03-08 11:55:42