Prediktivni značaj određivanja koncentracije vitamina D u bolesnika s rakom debeloga crijeva

doctoral thesis

• Title (english): Predictive significance of vitamin D in colorectal cancer patients
• Author: Zrna Antunac Golubić
• Mentor: Stjepko Pleština (mentor)
• Committee member: Vesna Kušec (predsjednik povjerenstva)
• Committee member: Borislav Belev (član povjerenstva)
• Committee member: Antonio Juretić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2020-12-08, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Oncology
• Universal decimal classification (UDC): 616 - Pathology. Clinical medicine

Abstract

Uvod: Istraživanja su pokazala da više koncentracije 25(OH)D u krvi smanjuju rizik za pojavu
raka debelog crijeva. Bolesnici s metastatskim rakom debelog crijeva imaju često
insuficijenciju D vitamina, ali utjecaj vitamina D na prognozu bolesti je još uvijek nerazjašnjen.
U našem istraživanju smo analizirali povezanost primjene kolekalciferola u dozi od 2000 ij s
preživljenjem bolesnika s metastatskim kolorektalnim karcinomom. -----
Ciljevi i metode istraživanja: U istraživanje je uključeno 72 bolesnika. Bolesnici s
koncentracijom 25(OH)D < 75 nmol/L su randomizirani u dvije skupine : prva skupina je
dobivala 2000 ij dnevno (do kraja praćenja) uz odgovarajuću onkološku terapiju, a druga
samo odgovarajuću onkološku terapiju. Glavni cilj istraživanja bilo je ukupno preživljenje, a
specifični ciljevi bili su vrijeme do progresije bolesti, prevalencija hipovitaminoze D te utjecaj
kolekalciferola na serumsku koncentraciju 25(OH)D. -----
Rezultati: 98,1 % bolesnika je imalo hipovitaminozu D. Nije bilo razlike u OS i PFS među
skupinama. Primjenom kolekalciferola u dozi 2000 ij nije došlo do adekvatnog porasta
koncentracije 25(OH)D u krvi. -----
Zaključak: Većina bolesnika imala je hipovitaminozu D. Dodavanjem kolekalciferola 2000 ij
dnevno kemoterapiji nismo poboljšali OS ni PFS.

Abstract (english)

Introduction: Some studies have demonstrated that higher baseline plasma levels of
25(OH)D are associated with a significant reduction in colorectal cancer (CRC) incidence.
Patients with mCRC tend to be vitamin D insufficient, but the effect of vitamin D on the
survival of mCRC patients still remains uncertain. In this study, we evaluated the association
between cholecalciferol 2,000 IU daily supplementation and survival of mCRC patients. -----
Aims and methods: Seventy-two patients with mCRC were included. Seventy-one patients
with 25(OH)D levels <75 nmol/L were randomized to receive standard chemotherapy or
standard chemotherapy with cholecalciferol 2,000 IU daily for six months. The primary
endpoint was overall survival (OS), and the secondary endpoints were progression-free
survival (PFS) and prevalence of vitamin D insufficiency. -----
Results: All but one patient (98.6%) was vitamin D insufficient. There was no statistically
significant difference in OS or PFS between those who received vitamin D supplements and
controls. -----
Conclusions: The majority of patients with mCRC are vitamin D insufficient at the time of
diagnosis. In our study, adding 2,000 IU of cholecalciferol daily for 2 yr to standard
chemotherapy did not show any benefit in OS or PFS.

• Keywords: Ljudi; Vitamin D; Holekalciferol; Učestalost; Rasprostranjenost; Vitamini; Dodaci prehrani; Kolorektalne novotvorine; Nedostatak vitamina D; Plazma; Referentni standardi
• Keywords (english): Humans; Vitamin D; Cholecalciferol; Incidence; Prevalence; Vitamins; Dietary Supplements; Colorectal Neoplasms; Vitamin D Deficiency; Plasma; Reference Standards
• Language: croatian
• URN:NBN: urn:nbn:hr:105:060470
• Project: Number: 108-1080058-0047; Title: Molekularni biljezi u solidnim tumorima - prediktivni i prognostički značaj; Title: The role of predictive and prognostic molecular markers in cancer treatment; Leader: Stjepko Pleština; Jurisdiction: Croatia; Funder: MZOS; Funding stream: ZP
• Study programme: Title: Biomedicine and Health Sciences; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
• Catalog URL: https://katalog.nsk.hr/F/19IT7Y755V1NXQJPHCLYSQGPF6BLAPPF179HQ7FAXXMYBYGMV5-02476?func=find-e&request=Prediktivni+zna%C4%8Daj+odre%C4%91ivanja+koncentracije+vitamina+D+u+bolesnika+s+rakom+debeloga+crijeva&find_scan_code=FIND_NAS&adjacent=N&local_base=MF_WEB&x=64&y=15&filter_code_1=WLN&filter_request_1=&filter_code_2=WYR&filter_request_2=&filter_code_3=WYR&filter_request_3=&filter_code_4=WFM&filter_request_4=
• Type of resource: Text
• Extent: 83 str.
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-03-19 08:51:55