Procjena vrijednosti BODE indeksa kao pokazatelja kardiorespiratorne funkcije nakon resekcije pluća zbog karcinoma bronha

doctoral thesis

• Title (english): Assessment of BODE index as indicator of cardiorespiratory function in lung resection for bronchial carcinoma
• Author: Vjekoslav Karadža; VIAF: 305653965
• Mentor: Dinko Stančić-Rokotov (mentor)
• Mentor: Jasna Špiček Macan (komentor)
• Committee member: Dinko Tonković (predsjednik povjerenstva)
• Committee member: Višnja Majerić-Kogler (član povjerenstva)
• Committee member: Slobodan Mihaljević (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2020-12-29, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Surgery
• Universal decimal classification (UDC): 616 - Pathology. Clinical medicine

Abstract

Uvod: BODE indeks uključuje FEV1 i 6-minutni test hodanja te bi se, u skladu s tim, BODE indeks mogao uključiti u selekciju bolesnika predviđenih za resekcijski zahvat na plućima zbog karcinoma bronha. Hipoteza: Resekcija pluća ne manja od lobektomije značajno će povećati vrijednost BODE indeksa u bolesnika s karcinomom bronha. ----- Materijali i metode: Sto bolesnika podvrgnuto je spirometriji i 6-minutnom testu hodanja, mMRC procjeni i izračunavanju BMI uz određivanje BODE indeksa tijekom prijeoperacijske pripreme i tijekom kontrolnog pregleda nakon jednog mjeseca postoperativno. ----- Rezultati: Statistička analiza prikupljenih podataka potvrdila je hipotezu (p<0,001). 11% bolesnika promjenom BODE indeksa koji su prije operacije pripadali kvartili s najboljom prognozom, promijenilo je pripadajuću kvartilu BODE indeksa, a time, moguće, i prognozu. Prije operacije nije bilo bolesnika u 3. i 4. kvartili, a poslije operacije 5% bolesnika pripalo je ovim skupinama. ----- Rasprava: Iako kombinirani pokazatelj, a ne jedinstveni test, BODE indeks mogao bi imati ulogu u procjeni rizika za bolesnike s KOPB-om koji se podvrgavaju resekcijskim zahvatima na plućima zbog karcinoma bronha.

Abstract (english)

Introduction: BODE index includes FEV1 and 6 minutes walk test, and, according to it, BODE index could be included in selection of patients undergone lung resection for bronchial carcinoma. ----- Hypothesis: Lung resection no less then lobectomy will significantly increase BODE index in patients with bronchial carcinoma. ----- Materials and methods: One hundred patients underwent spirometry and 6-minutes walk test, scoring of mMRC and BMI and scoring of BODE index during patient preparation before surgery and on control survey one month after surgery. ----- Results: Statistical analysis of collected data confirmed the hypothesis (p<0,001). 11% of patients belonging to the best prognostic BODE index quartile before surgery, changed the belonging quartile of BODE index after surgery, and, according to that, possibly, their prognosis. There were no patients in 3rd and 4th quartile before surgery. 5% of patients found themselves in these groups after surgery. ----- Discusion: Although a composite score rather then a single test, the BODE index could play a role in assessing the risk for COPD patients undergoing lung resection for bronchial cancer.

• Keywords: BODE indeks; karcinom; bronhogeni; torakalni kirurški zahvat; spirometrija; test tolerancije napora; 6-minutni test hodanja; FEV1
• Keywords (english): BODE index; Carcinoma; Bronchogenic; Pulmonary Surgical Procedure; Spirometry; Exercise Test; 6-minutes walk test; FEV1
• Language: croatian
• URN:NBN: urn:nbn:hr:105:292233
• Study programme: Title: Biomedicine and Health Sciences; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
• Catalog URL: https://katalog.nsk.hr/F/19IT7Y755V1NXQJPHCLYSQGPF6BLAPPF179HQ7FAXXMYBYGMV5-02255?func=find-e&request=Procjena+vrijednosti+BODE+indeksa+kao+pokazatelja+kardiorespiratorne+funkcije+nakon+resekcije+plu%C4%87a+zbog+karcinoma+bronha&find_scan_code=FIND_NAS&adjacent=N&local_base=MF_WEB&x=65&y=15&filter_code_1=WLN&filter_request_1=&filter_code_2=WYR&filter_request_2=&filter_code_3=WYR&filter_request_3=&filter_code_4=WFM&filter_request_4=
• Type of resource: Text
• Extent: 107 str.
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-03-24 12:53:44