PANDAS: dijagnostički i terapijski izazovi, prikaz bolesnika i pregled literature

master's thesis

• Title (english): PANDAS: diagnostic and therapeutic challenges, case report and literature review
• Author: Kristian Hodak
• Mentor: Marija Jelušić (mentor)
• Committee member: Jurica Vuković (predsjednik povjerenstva)
• Committee member: Irena Senečić-Čala (član povjerenstva)
• Committee member: Marija Jelušić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Pediatrics); Zagreb
• Defense date and country: 2020-07-17, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Pediatrics

Abstract

Pedijatrijski autoimunosni neuropsihijatrijski poremećaji udruženi sa streptokoknom infekcijom (PANDAS, engl. pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections) predstavljaju kontroverzni klinički entitet u
medicinskoj praksi zbog nedovoljno poznate etiopatogeneze, nepostojanja specifičnog biljega za potvrdu dijagnoze te teško dokazive uzročno-posljedične veze između infekcije ß-hemolitičkim streptokokom skupine A (BHSA) i pojave simptoma ovog poremećaja. Očituje se naglo nastalim simptomima i znakovima opsesivno-kompulzivnog poremećaja (OKP) i/ili tikovima, a koji su povezani s nedavnom infekcijom BHSA-om. U radu smo prikazali bolesnicu s PANDAS-om uz kratak pregled literature vezano uz etiopatogenezu, dijagnostiku i liječenje pri čemu smo željeli naglasiti složenost ovog poremećaja zbog velikih različitosti u kliničkoj slici, nemogućnosti postavljanja sigurne dijagnoze i prijepora u odabiru učinkovitih metoda liječenja. Iz navedenoga je razvidno da mnoga pitanja u svezi s PANDAS-om ostaju otvorena te da su potrebna daljnja istraživanja i multidisciplinarni pristup kako bi se
bolje upoznao ovaj kompleksni klinički entitet.

Abstract (english)

Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) is a controversial clinical entity in medical practice due to insufficiently known etiopathogenesis, lack of specific markers for confirmation of the diagnosis, and difficult-to-prove causal relationship between a group A ß-haemolytic streptococcal (GABHS) infection and the onset of symptoms. It presents with a sudden onset of symptoms and signs of obsessive-compulsive disorder (OCD) and/or tics, which are associated with a recent GABHS infection. We presented a patient with PANDAS as well as a brief overview of the literature concerning the etiopathogenesis, diagnostics and treatment while emphasizing the complexity of this disorder due to the large variations in clinical presentation, the inability to make a reliable diagnosis, and the controversies in choosing effective treatment methods. It is evident that many of the issues surrounding PANDAS remain open and that further research and a multidisciplinary approach are needed to better understand this complex clinical entity.

• Keywords: pedijatrijski autoimunosni neuropsihijatrijski poremećaj udružen sa streptokoknom infekcijom; streptokok skupine A; streptolizin; opsesivno-kompulzivni poremećaj; tikovi
• Keywords (english): pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections; group A streptococcal infection; antistreptolysin; obsessive-compulsive disorder; tics
• Language: croatian
• URN:NBN: urn:nbn:hr:105:084849
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-04-13 08:31:19