prikaz prve stranice dokumenta Validation of distinct pathogenic patterns in a cohort of membranoproliferative glomerulonephritis patients by cluster analysis
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Scientific paper - Original scientific paper
Validation of distinct pathogenic patterns in a cohort of membranoproliferative glomerulonephritis patients by cluster analysis
Clinical Kidney Journal, 13 (2019), 2; 225-234. https://doi.org/10.1093/ckj/sfz073
Garam, Nóra; Prohászka, Zoltán; Szilágyi, Ágnes; Aigner, Christof; Schmidt, Alice; Gaggl, Martina; Sunder-Plassmann, Gere; Bajcsi, Dóra; Brunner, Jürgen; Dumfarth, Alexandra; Cejka, Daniel; Flaschberger, Stefan; Flögelova, Hana; Haris, Ágnes; Hartmann, Ágnes; Heilos, Andreas; Mueller, Thomas; Rusai, Krisztina; Arbeiter, Klaus; Hofer, Johannes; Jakab, Dániel; Sinkó, Mária; Szigeti, Erika; Bereczki, Csaba; Janko, Viktor; Kelen, Kata; Reusz, György S; Szabó, Attila J; Klenk, Nóra; Kóbor, Krisztina; Kojc, Nika; Knechtelsdorfer, Maarten; Laganović, Mario; Lungu, Adrian Catalin; Meglic, Anamarija; Rus, Rina; Kersnik-Levart, Tanja; Macioniene, Ernesta; Miglinas, Marius; Pawłowska, Anna; Stompór, Tomasz; Podracka, Ludmila; Rudnicki, Michael; Mayer, Gert; Rysava, Romana; Reiterova, Jana; Saraga, Marijan; Seeman, Tomáš; Zieg, Jakub; Sládková, Eva; Szabó, Tamás; Capitanescu, Andrei; Stancu, Simona; Tišljar, Miroslav; Galešić, Krešimir; Tislér, András; Vainumäe, Inga; Windpessl, Martin; Zaoral, Tomas; Zlatanova, Galia; Csuka, Dorottya More authors...

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Garam, N., Prohászka, Z., Szilágyi, Á., Aigner, C., Schmidt, A., Gaggl, M. ... Csuka, D. (2019). Validation of distinct pathogenic patterns in a cohort of membranoproliferative glomerulonephritis patients by cluster analysis. Clinical Kidney Journal, 13. (2), 225-234. doi: 10.1093/ckj/sfz073

Garam, Nóra, et al. "Validation of distinct pathogenic patterns in a cohort of membranoproliferative glomerulonephritis patients by cluster analysis." Clinical Kidney Journal, vol. 13, no. 2, 2019, pp. 225-234. https://doi.org/10.1093/ckj/sfz073

Garam, Nóra, Zoltán Prohászka, Ágnes Szilágyi, Christof Aigner, Alice Schmidt, Martina Gaggl, Gere Sunder Plassmann, et al. "Validation of distinct pathogenic patterns in a cohort of membranoproliferative glomerulonephritis patients by cluster analysis." Clinical Kidney Journal 13, no. 2 (2019): 225-234. https://doi.org/10.1093/ckj/sfz073

Garam, N., et al. (2019) 'Validation of distinct pathogenic patterns in a cohort of membranoproliferative glomerulonephritis patients by cluster analysis', Clinical Kidney Journal, 13(2), pp. 225-234. doi: 10.1093/ckj/sfz073

Garam N, Prohászka Z, Szilágyi Á, Aigner C, Schmidt A, Gaggl M, and sur.. Validation of distinct pathogenic patterns in a cohort of membranoproliferative glomerulonephritis patients by cluster analysis. Clinical Kidney Journal [Internet]. 2019 June 21 [cited 2024 December 19];13(2):225-234. doi: 10.1093/ckj/sfz073

N. Garam, et al., "Validation of distinct pathogenic patterns in a cohort of membranoproliferative glomerulonephritis patients by cluster analysis", Clinical Kidney Journal, vol. 13, no. 2, pp. 225-234, June 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:252219. [Accessed: 19 December 2024]

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Metadata
Title (english)Validation of distinct pathogenic patterns in a cohort of membranoproliferative glomerulonephritis patients by cluster analysis
AuthorNóra Garam
AuthorZoltán Prohászka
AuthorÁgnes Szilágyi
AuthorChristof Aigner
AuthorAlice Schmidt
AuthorMartina Gaggl
AuthorGere Sunder-Plassmann
AuthorDóra Bajcsi
AuthorJürgen Brunner
AuthorAlexandra Dumfarth
AuthorDaniel Cejka
AuthorStefan Flaschberger
AuthorHana Flögelova
AuthorÁgnes Haris
AuthorÁgnes Hartmann
AuthorAndreas Heilos
AuthorThomas Mueller
AuthorKrisztina Rusai
AuthorKlaus Arbeiter
AuthorJohannes Hofer
AuthorDániel Jakab
AuthorMária Sinkó
AuthorErika Szigeti
AuthorCsaba Bereczki
AuthorViktor Janko
AuthorKata Kelen
AuthorGyörgy S Reusz
AuthorAttila J Szabó
AuthorNóra Klenk
AuthorKrisztina Kóbor
AuthorNika Kojc
AuthorMaarten Knechtelsdorfer
AuthorMario Laganović
AuthorAdrian Catalin Lungu
AuthorAnamarija Meglic
AuthorRina Rus
AuthorTanja Kersnik-Levart
AuthorErnesta Macioniene
AuthorMarius Miglinas
AuthorAnna Pawłowska
AuthorTomasz Stompór
AuthorLudmila Podracka
AuthorMichael Rudnicki
AuthorGert Mayer
AuthorRomana Rysava
AuthorJana Reiterova
AuthorMarijan Saraga
AuthorTomáš Seeman
AuthorJakub Zieg
AuthorEva Sládková
AuthorTamás Szabó
AuthorAndrei Capitanescu
AuthorSimona Stancu
AuthorMiroslav Tišljar
AuthorKrešimir Galešić
AuthorAndrás Tislér
AuthorInga Vainumäe
AuthorMartin Windpessl
AuthorTomas Zaoral
AuthorGalia Zlatanova
AuthorDorottya Csuka
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Background: A novel data-driven cluster analysis identified distinct pathogenic patterns in C3-glomerulopathies and immune complex-mediated membranoproliferative glomerulonephritis. Our aim was to replicate these observations in an independent cohort and elucidate disease pathophysiology with detailed analysis of functional complement markers. ----- Methods: A total of 92 patients with clinical, histological, complement and genetic data were involved in the study, and hierarchical cluster analysis was done by Ward method, where four clusters were generated. ----- Results: High levels of sC5b-9 (soluble membrane attack complex), low serum C3 levels and young age at onset (13 years) were characteristic for Cluster 1 with a high prevalence of likely pathogenic variations (LPVs) and C3 nephritic factor, whereas for Cluster 2-which is not reliable because of the small number of cases-strong immunoglobulin G staining, low C3 levels and high prevalence of nephritic syndrome at disease onset were observed. Low plasma sC5b-9 levels, decreased C3 levels and high prevalence of LPV and sclerotic glomeruli were present in Cluster 3, and patients with late onset of the disease (median: 39.5 years) and near-normal C3 levels in Cluster 4. A significant difference was observed in the incidence of end-stage renal disease during follow-up between the different clusters. Patients in Clusters 3-4 had worse renal survival than patients in Clusters 1-2. ----- Conclusions: Our results confirm the main findings of the original cluster analysis and indicate that the observed, distinct pathogenic patterns are replicated in our cohort. Further investigations are necessary to analyse the distinct biological and pathogenic processes in these patient groups.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleClinical Kidney Journal
Numberingvol. 13, no. 2, pp. 225-234
p-ISSN2048-8505
e-ISSN2048-8513
DOIhttps://doi.org/10.1093/ckj/sfz073
URN:NBNurn:nbn:hr:105:252219
Publication2019-06-21
Document URLhttps://academic.oup.com/ckj/article/13/2/225/5521776
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2021-04-13 11:27:07