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Scientific paper - Original scientific paper
IL-1β, IL-6, IL-10, and TNFα Single Nucleotide Polymorphisms in Human Influence the Susceptibility to Alzheimer’s Disease Pathology
Journal of Alzheimer's Disease, 75 (2020), 3; 1029-1047. https://doi.org/10.3233/JAD-200056
Babić Leko, Mirjana; Nikolac Perković, Matea; Klepac, Nataša; Švob Štrac, Dubravka; Borovečki, Fran; Pivac, Nela; Hof, Patrick R.; Šimić, Goran

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Babić Leko, M., Nikolac Perković, M., Klepac, N., Švob Štrac, D., Borovečki, F., Pivac, N. ... Šimić, G. (2020). IL-1β, IL-6, IL-10, and TNFα Single Nucleotide Polymorphisms in Human Influence the Susceptibility to Alzheimer’s Disease Pathology. Journal of Alzheimer's Disease, 75. (3), 1029-1047. doi: 10.3233/JAD-200056

Babić Leko, Mirjana, et al. "IL-1β, IL-6, IL-10, and TNFα Single Nucleotide Polymorphisms in Human Influence the Susceptibility to Alzheimer’s Disease Pathology." Journal of Alzheimer's Disease, vol. 75, no. 3, 2020, pp. 1029-1047. https://doi.org/10.3233/JAD-200056

Babić Leko, Mirjana, Matea Nikolac Perković, Nataša Klepac, Dubravka Švob Štrac, Fran Borovečki, Nela Pivac, Patrick R. Hof and Goran Šimić. "IL-1β, IL-6, IL-10, and TNFα Single Nucleotide Polymorphisms in Human Influence the Susceptibility to Alzheimer’s Disease Pathology." Journal of Alzheimer's Disease 75, no. 3 (2020): 1029-1047. https://doi.org/10.3233/JAD-200056

Babić Leko, M., et al. (2020) 'IL-1β, IL-6, IL-10, and TNFα Single Nucleotide Polymorphisms in Human Influence the Susceptibility to Alzheimer’s Disease Pathology', Journal of Alzheimer's Disease, 75(3), pp. 1029-1047. doi: 10.3233/JAD-200056

Babić Leko M, Nikolac Perković M, Klepac N, Švob Štrac D, Borovečki F, Pivac N, and sur.. IL-1β, IL-6, IL-10, and TNFα Single Nucleotide Polymorphisms in Human Influence the Susceptibility to Alzheimer’s Disease Pathology. Journal of Alzheimer's Disease [Internet]. 2020 June 02 [cited 2024 April 20];75(3):1029-1047. doi: 10.3233/JAD-200056

M. Babić Leko, et al., "IL-1β, IL-6, IL-10, and TNFα Single Nucleotide Polymorphisms in Human Influence the Susceptibility to Alzheimer’s Disease Pathology", Journal of Alzheimer's Disease, vol. 75, no. 3, pp. 1029-1047, June 2020. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:478592. [Accessed: 20 April 2024]

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Metadata
Title (english)IL-1β, IL-6, IL-10, and TNFα Single Nucleotide Polymorphisms in Human Influence the Susceptibility to Alzheimer’s Disease Pathology
AuthorMirjana Babić Leko
AuthorMatea Nikolac Perković
AuthorNataša Klepac
AuthorDubravka Švob Štrac
AuthorFran Borovečki
AuthorNela Pivac
AuthorPatrick R. Hof
AuthorGoran Šimić
Author's institutionUniversity of Zagreb
School of Medicine
(Croatian Institiute for Brain Research)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Neurology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Neurology
Abstract (english)
Background: Neuroinflammation plays an important role in Alzheimer's disease (AD). During this process, activated microglia release pro-inflammatory cytokines such as interleukin (IL)-1α, IL-1β, IL-6, and tumor necrosis factor α (TNFα) that participate in neuron damage, but also anti-inflammatory cytokines (such as IL-10), which maintain homeostasis of immune response. Previous studies showed the association of IL-1α -889C/T (rs1800587), IL-1β-1473G/C (rs1143623), IL-6 -174C/G (rs1800795), IL-10 -1082G/A (rs1800896), and TNFα -308A/G (rs1800629) polymorphisms with AD. ----- Objective: We aimed to investigate whether people with certain IL-1α, IL-1β, IL-6, IL-10, and TNFα genotypes in these polymorphisms are more prone to develop AD-related pathology, reflected by pathological levels of cerebrospinal fluid (CSF) AD biomarkers including amyloid-β1-42, total tau (t-tau), tau phosphorylated at Thr 181 (p-tau181), Ser 199 (p-tau199), and Thr 231 (p-tau231), and visinin-like protein 1 (VILIP-1). ----- Methods: The study included 115 AD patients, 53 patients with mild cognitive impairment, and 11 healthy controls. The polymorphisms were determined using real-time polymerase chain reaction. Levels of CSF biomarkers were determined by enzyme-linked immunosorbent assay. ----- Results: A significant increase in p-tau CSF levels was found in patients with the AA IL-10 -1082G/A and GG TNFα -308A/G genotypes, and in carriers of a G allele in IL-1β -1473C/G and IL-6 -174C/G polymorphisms. t-tau levels were increased in carriers of a G allele in IL-1β -1473C/G polymorphism. An increase in VILIP-1 levels was observed in patients with CG and GG IL-1β -1473C/G, GC IL-6 -174C/G, and GG TNFα -308A/G genotype. ----- Conclusion: These results suggest that persons carrying certain genotypes in IL10 (-1082G/A), IL1β (1473C/G), IL6 (-174C/G), and TNFIα (-308A/G) could be more vulnerable to development of neuroinflammation, and consequently of AD.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleJournal of Alzheimer's Disease
Numberingvol. 75, no. 3, pp. 1029-1047
p-ISSN1387-2877
e-ISSN1875-8908
DOIhttps://doi.org/10.3233/JAD-200056
URN:NBNurn:nbn:hr:105:478592
Publication2020-06-02
Document URLhttps://www.medra.org/servlet/aliasResolver?alias=iospress&doi=10.3233/JAD-200056
Type of resourceText
Access conditionsOpen access
Embargo expiration date: 2021-07-01
Terms of useLicence In copyright icon
Created on2021-04-21 11:08:25