Kvaliteta suznog filma u kroničnih shizofrenih bolesnika na dugotrajnoj terapiji antipsihoticima

doctoral thesis

• Title (english): Quality of tear film in chronic shizophrenic patients on long term antipsychotic therapy
• Author: Ivana Bakija; VIAF: 305652076
• Mentor: Igor Filipčić (mentor)
• Mentor: Snježana Kaštelan (komentor)
• Committee member: Dražen Begić (predsjednik povjerenstva)
• Committee member: Marina Šagud (član povjerenstva)
• Committee member: Nenad Vukojević (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2021-04-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Psychiatry
• Universal decimal classification (UDC): 616 - Pathology. Clinical medicine

Abstract

Cilj: U ovom opservacijskom presječnom istraživanju cilj je bio ispitati kvalitetu suznog
filma u kroničnih shizofrenih bolesnika na dugotrajnoj terapiji antipsihoticima te s time
povezanu disfunkciju suznog filma. -----
Metode: U istraživanje je bilo uključeno 160 ispitanika, 80 shizofrenih bolesnika koji
uzimaju jedan od tri antipsihotika (tzv. „-pini“) i 80 zdravih ispitanika kontrolne skupine.
Svim ispitanicima učinjen je oftalmološki pregled koji je uključivao ispunjavanje upitnika o
subjektivnim simptomima suhog oka (OSDI upitnik) te tri objektivna mjerenja: Schirmerov
test mjerenja produkcije suza, Test mjerenja vremena pucanja suznog filma (TBUT test) i
Test bojenja fluoresceinom. -----
Rezultati: Dobiveni rezultati pokazuju da postoji statistički značajna razlika (p < 0,01) u svim
subjektivnim mjerama na OSDI upitniku između dvije skupine. Kod svih varijabli vezanih za
simptome, vidnu funkciju i utjecaje okoliša, viši prosječni rezultat postižu ispitanici sa
shizofrenijom u odnosu na kontrolnu skupinu. Također smo dobili statistički značajnu razliku
(p < 0,01) u svim objektivnim mjerama između ispitivane i kontrolne skupine. Spearmanov
koeficijent korelacije pokazuje da su sve mjere disfunkcije suznog filma, statistički značajno
(p < 0,01) povezane s duljinom korištenja antipsihotika. -----
Zaključak: Kod planiranog dugotrajnog uzimanja antipsihotika treba uzeti u obzir mogućnost
pojave simptoma disfunkcije suznog filma te potrebe oftalmološkog pregleda i tretmana čime
bi poboljšali kvalitetu života i svakodnevno funkcioniranje bolesnika sa shizofrenijom.

Abstract (english)

Objectives: In this opservational cross-sectional study the objective was to prove that longterm
use of antipsychotics in patients with schizophrenia causes damage to the quality of the
tear film. -----
Methods: The study was conducted on a sample of 160 participants, 80 schizophrenic
patients taking antipsychotics, and 80 healthy controls. All participants were undergo an
ophthalmologic examination, consisting of filling the questionnaire on subjective symptoms
(OSDI) and three objective tests: Schirmer test that measures tear production, TBUT – test
measuring tear break-up time and fluorescein eye staining test. -----
Results: We got significantly different results (p < 0,01) in all subjective simptoms in OSDI
questionnaire between two groups. In all variables regarding symptoms, visible function and
environmental impact, higher average score achieve schizophrenic patients than controls.
Also, we got significantly different results (p < 0,01) in all objective tests between two
groups. With Spearmann correlation coefficient we got data that all tear film dysfunction tests
are significantly (p < 0,01) related with time duration of use of antipsyhotic drug. -----
Conclusions: In planning long-term use of antipsyhotics, it should be consider posibilities of
dry eye symptoms and need for ophtalmological examination and treatment that we can act on
improve quality of life and functioning of patients with schizophrenia.

• Keywords: shizofrenija; antipsihotici; suzni film; disfunkcija suznog filma
• Keywords (english): schizophrenia; antipsyhotics; tear film; tear film dysfunction
• Language: croatian
• URN:NBN: urn:nbn:hr:105:936456
• Study programme: Title: Biomedicine and Health Sciences; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
• Type of resource: Text
• Extent: 112 str.
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-05-05 12:03:17