Prognostička uloga upalnih pokazatelja u bolesnika s disekcijom aorte

master's thesis

• Title (english): Prognostic role of inflammatory markers in patients with aortic dissection
• Author: Lovorka Matković
• Mentor: Mislav Vrsalović (mentor)
• Committee member: Zdravko Babić (predsjednik povjerenstva)
• Committee member: Martina Lovrić Benčić (član povjerenstva)
• Committee member: Mislav Vrsalović (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2020-07-17, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract

Disekcija aorte je hitno stanje s visokim mortalitetom, čak i uz napredne metode dijagnostike i liječenja. Brojni radovi opisuju važnu ulogu upale u patogenezi i razvoju disekcije aorte te u periodu nakon njezina nastanka. Cilj ovog rada je analizirati prognostičku ulogu upalnih pokazatelja u bolesnika s disekcijom aorte tipa A. Za pretraživanje radova korištena je baza podataka Medline. Korišteno je ručno pretraživanje i pretraživanje pomoću ključnih riječi. Radovi su prvo isključeni na temelju naslova
i sažetka, a onda pregledom cijelog teksta rada. U ovaj sustavni pregled literature uključeno je ukupno 26 radova. Uključeni radovi analiziraju broj leukocita, broj trombocita, koncentraciju D-dimera, koncentraciju C-reaktivnog proteina i koncentraciju
fibrinogena u krvi u bolesnika s disekcijom aorte tipa A. Navedeni upalni pokazatelji u radovima su prikazani odvojeno za preživjele i preminule bolesnike. U ovom radu uspoređene su laboratorijske vrijednosti upalnih pokazatelja u preživjelih i preminulih bolesnika. Rezultati usporedbe pokazuju povezanost broja leukocita i trombocita te koncentracije D-dimera, C-reaktivnog proteina i fibrinogena s bolničkim mortalitetom. U preminulih bolesnika broj leukocita u krvi je veći, broj trombocita u krvi je manji, koncentracija D-dimera u krvi je veća, koncentracija C-reaktivnog proteina u krvi je veća, a koncentracija fibrinogena u krvi je manja u usporedbi s vrijednostima u preživjelih bolesnika. Ovaj sustavni pregled literature potvrđuje moguću prognostičku ulogu upalnih pokazatelja u bolesnika s disekcijom aorte tipa A.

Abstract (english)

Aortic dissection is a medical emergency with high mortality, even with today’s advanced diagnostic and therapeutic methods. Numerous studies describe an important role of inflammation in the parthenogenesis and development of aortic dissection and in the period after its occurrence. The aim of this thesis was to analyze the prognostic role of inflammatory biomarkers in patients with type A aortic dissection. The Medline database was searched for related articles. The search was performed by keywords and additionally by a manual search. First, articles were excluded based on title and abstract, then the full texts were evaluated in detail. Finally, 26 articles were included in this systematic review. The included articles analyze white blood cell count, platelet count and plasma concentration of D-dimer, C-reactive protein and fibrinogen in patients with type A aortic dissection. All these inflammatory biomarkers were provided separately for survived and deceased patients. In this thesis, the values of inflammatory biomarkers in survived and deceased patients were compared. The comparison showed an association between white blood cell and platelet count and plasma concentration of D-dimer, C-reactive protein and fibrinogen with in-hospital mortality. The deceased patients had higher white blood cell counts, lower platelet counts, higher concentrations of D-dimer and C-reactive protein and lower concentrations of fibrinogen compared to the survived patients. This systematic review indicates a prognostic role of inflammatory biomarkers in patients with type A aortic dissection.

• Keywords: disekcija aorte; upala; prognostička uloga; mortalitet
• Keywords (english): aortic dissection; inflammation; prognostic role; mortality
• Language: croatian
• URN:NBN: urn:nbn:hr:105:530743
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-05-06 11:25:42