The Association between TNF-alpha, IL-1 alpha and IL-10 with Alzheimer's Disease

Scientific paper - Original scientific paper

• Author: Marija Čuljak
• Author: Matea Nikolac Perković
• Author: Suzana Uzun
• Author: Dubravka Švob Štrac
• Author: Gordana Nedić Erjavec
• Author: Mirjana Babić Leko
• Author: Goran Šimić
• Author: Lucija Tudor
• Author: Marcela Konjevod
• Author: Oliver Kozumplik
• Author: Ninoslav Mimica
• Author: Nela Pivac
• Author's institution: University of Zagreb; School of Medicine; (Croatian Institiute for Brain Research)
• Author's institution: University of Zagreb; School of Medicine; (Department of Psychiatry and Psychological Medicine)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Psychiatry
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Basic Medical Sciences; Neuroscience

Abstract (english)

Background: Sporadic Alzheimer's Disease (AD) is assumed to be associated with different biological/genetic vulnerability, as well as with neuroinflammation, mediated by cytokines. The present study evaluated the role of cytokines in AD.
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Objective: The aim was to determine the possible association of TNF-α (rs1800629), IL1-α (rs1800587) and IL-10 (rs1800896) polymorphisms with AD, and to assess serum TNF-α, IL-1α and IL-10 concentrations in patients with AD and in subjects with mild cognitive impairment (MCI).
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Methods: The study included 645 Caucasian participants: 395 subjects with AD and 250 subjects with MCI. Genotyping was performed using real-time PCR in all 645 subjects, while serum concentrations of TNF-α, IL-1α and IL-10 and were determined using ELISA in 174 subjects.
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Results: The frequency of the TNF-α rs1800629, IL1-α rs1800587 or IL-10 rs1800896 genotypes did not differ significantly between patients with AD and MCI. Serum concentration of IL-1α and IL-10 were significantly decreased, while the concentration of TNF-α was significantly higher in patients with AD than in MCI subjects. TNF-α, IL1-α or IL-10 concentrations were similar in subjects with AD or MCI subdivided into carriers of the corresponding TNF-α rs1800629, IL1-α rs1800587 or IL-10 rs1800896 genotypes.
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Conclusion: Similar distribution of the IL1-α rs1800587, TNF-α rs1800629 or IL-10 rs1800896 genotypes in subjects with AD and MCI failed to confirm that these specific risk genotypes are associated with vulnerability to develop AD. Alteration in IL-1α, IL-10 and TNF-α concentrations in patients with AD partially confirmed the association with the neuroinflammatory response in AD.

• Keywords (english): Alzheimer's disease; IL-10; IL-10 rs1800896; IL-1α; IL1-α rs1800587; TNF-α; TNF-α rs1800629; mild cognitive impairment
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Accepted version
• Journal title: Current Alzheimer Research
• Numbering: vol. 17, no. 11, pp. 972-984
• p-ISSN: 1567-2050
• e-ISSN: 1875-5828
• DOI: https://doi.org/10.2174/1567205017666201130092427
• URN:NBN: urn:nbn:hr:105:201249
• Publication: 2021-01-21
• Document URL: https://www.eurekaselect.com/188488/article
• Type of resource: Text
• Access conditions: Open access; Embargo expiration date: 2021-12-01
• Created on: 2021-05-20 08:15:46