Modeli za testiranje potencijalnih anksiolitika na "anksioznom" mišu in vivo

master's thesis

• Title (english): Models for in vivo testing of potential anxiolytics in an "anxious" mouse
• Author: Tin Luka Petanjek
• Mentor: Ante Tvrdeić (mentor)
• Committee member: Predrag Sikirić (predsjednik povjerenstva)
• Committee member: Jasenka Markeljević (član povjerenstva)
• Committee member: Ante Tvrdeić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Pharmacology); Zagreb
• Defense date and country: 2020-07-17, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Basic Medical Sciences; Pharmacology

Abstract

Anksiozni poremećaji smatraju se jednim od najčešćih duševnih poremećaja te se vjeruje da će velik dio populacije tijekom života ispuniti kriterije za barem jedan od anksioznih poremećaja. Karakterizirani su situacijski neprimjerenim strahom, panikom ili uz njih vezanim ponašanjem. Anksiozni poremećaji se međusobno razlikuju ovisno o situaciji u kojoj se pojavljuju ili simptomima koje iskazuju, te ih je moguće kategorizirati prema DSM-5 ili MKB-10 klasifikacijama. Smatra se kako do anksioznih poremećaja dolazi zbog disfunkcije u amigdala ili CSTC krugovima te njihovim neuronskim vezama s mnogim moždanim strukturama. Među neurotransmitere uključene u anksiozne poremećaje ubrajamo GABA-u, serotonin i kateholamine. Sustavi neurotransmitera ujedno su i cilj terapije anksioznih poremećaja te su danas najčešće upotrebljavani benzodiazepini, SSRI ili SNRI te buspiron čiji učinak je usmjeren na modulaciju, te spojevi s djelovanjem na periferne adrenergičke receptore koji imaju utjecaj na simptome anksioznih poremećaja. Kako bismo analizirali anksiozne poremećaje i uz njih vezane obrasce ponašanja te djelovanje farmakoloških pripravaka upotrebljavamo životinjske modele. Modele je potrebno vrjednovati kako bi se odredila njihova učinkovitost u analizi određenog poremećaja, djelovanja određenog anksiolitika ili primjenjivost opažanja u životinjskim modelima na ljude. U upotrebi su mnoge životinjske vrste poput štakora, miševa, zebra ribice i zamoraca, te razni oblici uređaja za testiranje.

Abstract (english)

Anxiety disorders are considered to be one of the most common mental disorders and it is believed that a large portion of the population will meet criteria for at least one anxiety disorder during their lifetime. They are characterized by situationally inappropriate fear, panic, or related behavior. Anxiety disorders differ from each other depending on the situation in which they occur or symptoms they exhibit and can be categorized according to DSM-5 or ICD-10 classifications. Anxiety disorders are thought to occur due to dysfunction in the amygdala or CSTC circuits and their neural connections to many brain structures. Neurotransmitters involved in anxiety disorders include GABA, serotonin, and catecholamines. Neurotransmitter systems are also the goal of anxiety disorder therapy. Today the most commonly used medicines are benzodiazepines, SSRIs or SNRIs and buspirone, whose effect is directed at modulation, and compounds with effects on peripheral adrenergic receptors that affect the symptoms of anxiety disorders. In order to analyze anxiety disorders and related behavioral patterns and the action of pharmacological agents, we use animal models. Models need to be evaluated to determine their effectiveness in analyzing a particular disorder, the action of a particular anxiolytic, or the applicability of observations in animal models to humans. Many animal species such as rats, mice, zebra fish and guinea pigs, and various forms of testing devices are in use.

• Keywords: anksiozni poremećaji; amigdala; anksiolitici; životinjski modeli
• Keywords (english): anxiety disorders; amygdala; anxiolytics; animal models
• Language: croatian
• URN:NBN: urn:nbn:hr:105:392337
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-08-24 09:04:28