Mezenhimalne matične ili medicinske signalne stanice u imunomodulatornom i regenerativnom liječenju djece

master's thesis

• Title (english): Mesenchymal stem or medicinal signaling cells in immunomodulatory and regenerative treatment of children
• Author: Barbara Iveković
• Mentor: Mario Ćuk (mentor)
• Committee member: Vesna Lukinović Škudar (predsjednik povjerenstva)
• Committee member: Marija Jelušić (član povjerenstva)
• Committee member: Mario Ćuk (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Pediatrics); Zagreb
• Defense date and country: 2020-07-17, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Pediatrics

Abstract

Mezenhimalne matične stanice (MSC) predstavljaju skupinu multipotentnih stanica izoliranih iz humane koštane srži i periosta, koje in vitro zadržavaju sposobnost diferencijacije u brojna tkiva mezodermalnog podrijetla: osteoblaste, hondroblaste, mioblaste, stromalne stanice, fibroblaste i adipocite, pod uvjetima određene stanične kulture. S vremenom se uvidjelo da mogu biti izolirane iz gotovo svih tkiva ljudskog tijela budući da nastaju od pericita, perivaskularnih stanica, te da imaju dodatne karakteristike. In vivo, njihova uloga primarno je usmjerena na lučenje bioaktivnih čimbenika koji prepoznaju mjesto ozljede ili upale, posreduju u imunološkom odgovoru, smanjuju upalu i potiču regeneraciju tkiva. Zbog tih svojstava tendencija je promijeniti im ime u medicinske signalne stanice. Zahvaljujući svojstvima koja su naknadno otkrivena, danas se MSC koriste u pretkliničkim i kliničkim istraživanjima kao potencijalna terapija brojnih bolesti različitih organskih sustava (npr. za liječenje GVHD-a, infarkta miokarda, astme, bronhopulmonalne displazije, multiple skleroze, osteoartritisa, SLE, transplantacije organa itd.) gdje pokazuju obećavajuće rezultate. Cilj ovog diplomskog rada jest sakupiti nova saznanja o dobro poznatim stanicama te njihovoj mogućoj primjeni u kliničkoj praksi, što je od velike važnosti za liječenje određenih patoloških stanja, posebice u pedijatrijskoj populaciji.

Abstract (english)

Mesenchymal stem cells (MSCs) represent a group of multipotent cells isolated from human bone marrow and periosteum that retain in vitro ability to differentiate into various tissues of mesodermal origin: osteoblasts, chondroblasts, myoblasts, stromal cells, fibroblasts and adipocytes, under the conditions of a particular cell culture. Over time, it has become apparent that they can be isolated from almost all tissues of the human body as they arise from pericytes, perivascular cells, and have additional characteristics. In vivo, their role is primarily focused on secreting bioactive factors that recognize the site of injury or inflammation, mediate the immune response, reduce inflammation, and promote tissue regeneration. Because of these properties, the tendency is to change their name to medical signaling cells. Due to the properties discovered, MSCs are used nowadays in preclinical and clinical research as a potential therapy for numerous diseases of different organ systems (e.g. for the treatment of GVHD, myocardial infarction, asthma, bronchopulmonary dysplasia, multiple sclerosis, osteoarthritis, SLE, transplants organs etc.) where they show promising results. The aim of this thesis is to summarize new knowledge about the well-known cells and their possible application in clinical practice, which is of great importance for the treatment of certain pathological conditions, especially in the pediatric population.

• Keywords: mezenhimalne matične stanice; medicinske signalne stanice; imunomodulacija; regeneracija tkiva
• Keywords (english): mesenchymal stem cells; medicinal signaling cells; immunomodulation; regeneration of tissue
• Language: croatian
• URN:NBN: urn:nbn:hr:105:523552
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-08-30 07:54:47