Clinical features and complications of advanced heart failure: single center follow up

master's thesis

• Title (croatian): Kliničke prezentacije i komplikacije uznapredovale srčane dekompenzacije: jednocentrično prospektivno istraživanje
• Author: Ilona Arih
• Mentor: Vesna Degoricija (mentor)
• Committee member: Vesna Degoricija (predsjednik povjerenstva)
• Committee member: Matias Trbušić (član povjerenstva)
• Committee member: Martina Lovrić Benčić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2020-07-17, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Intensive Care

Abstract

INTRODUCTION: Heart failure is a complex clinical syndrome that develops when adequate cardiac output cannot be maintained and can be accompanied by elevated intracardiac pressures. Advanced heart failure is a common cause of admission to hospital, and one with significant morbidity and mortality. ----- OBJECTIVE: The aim of the present study was to better understand the presentation and clinical features of advanced heart failure patients, as well as provide perspective on complications and mortality rate. ----- METHODS: This study was a prospective cohort study of patients presenting to the Emergency Department of Sisters of Charity University Hospital Centre, Zagreb, Croatia between February 23rd 2018 and March 29th 2019 for primary reason of presentation for acute heart failure. ----- RESULTS: The key clinical features that patients presented with were those of pulmonary congestion with dyspnea being present in 89.7% of all patients, and decreased exercise tolerance in 91.4%. The most common complications were cardiac arrhythmias (63.5%) and impaired kidney function (60.3%). Patients had an average three, six and twelve-month mortality rate of 23.9%, 34.8% and 43.5% respectively. ----- CONCLUSION: Identifying the presenting clinical features and complications of advanced heart failure may help reduce its mortality, which is fairly high. Mortality rates are greater in HFpEF group of patients, suggesting these patients may need closer observation and management.

Abstract (croatian)

UVOD: Zatajenje srca je složen klinički sindrom koji se razvija kada se ne može održavati adekvatan srčani rad te može biti praćen povišenim intrakardijalnim pritiscima. Uznapredovala srčana dekompenzacija česti je uzročnik hospitalizacije sa
značajnim morbiditetom i mortalitetom. ----- CILJ: Cilj ovoga rada je bolje razumijevanje prezentacije i kliničkih značajki bolesnika s uznapredovalom srčanom insuficijencijom, kao i pružanje perspektive o komplikacijama i stopi smrtnosti. ----- METODE: Ovo istraživanje bilo je prospektivno kohortno istraživanje bolesnika liječenih u Kliničkom bolničkom centru Sestre milosrdnice između 23.02.2018. I 29.03.2019 radi akutnog zatajenja srca. ----- REZULTATI: Glavne kliničke značajke bolesnika bile plućni edem (dispneja bila je prisutna u 89.7% bolesnika) i smanjena tolerancija napora (91.4%). Najčešće komplikacije su bile srčane aritmije (63.5%) i oštećenje bubrežne funkcije (60.3%). Prosječan tri-, šest- i dvanaest-mjesečni mortalitet bio je 23.9%, 34.8% i 43.5%. ----- ZAKLJUČAK: Prepoznavanje postojećih kliničkih značajki i komplikacija uznapredovalog zatajenja srca može pomoći u smanjenju smrtnosti, koja je prilično visoka. Stope smrtnosti veće su u skupini bolesnika sa sačuvanom ejekcijskom frakcijom, što sugerira da ovi bolesnici treba pažljivije promatranje i obradu.

• Keywords: heart failure; clinical syndrome; intracardiac pressures; pulmonary congestion; cardiac arrhythmias
• Keywords (croatian): zatajenje srca; klinički sindrom; intrakardijalni pritisci; plućni edem; srčane aritmije
• Language: english
• URN:NBN: urn:nbn:hr:105:059637
• Study programme: Title: Medicine (in English language); Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Public note: Pohranitelj objekta unio ključne riječi.
• Created on: 2021-10-01 08:02:57