Platelet aggregation defects in women with endometriosis

master's thesis

• Title (croatian): Poremećaji agregacije trombocita u žena s endometriozom
• Author: Mohammad Omar Rahimy
• Mentor: Lana Škrgatić (mentor)
• Committee member: Lana Škrgatić (predsjednik povjerenstva)
• Committee member: Mario Ćorić (član povjerenstva)
• Committee member: Dinka Pavičić Baldani (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Gynecology and Obstetrics); Zagreb
• Defense date and country: 2020-07-17, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Gynecology and Obstetrics

Abstract

Major progress has been seen in the past few decades in the management of gynecological conditions and obstetric care in women with bleeding disorders (BDs). However, there remain many ambiguous issues within the field. A sequence of observational studies was conducted to address these issues with a goal to improve patient care. In the recent findings showing that platelets play important roles in the development of endometriosis. Hence, this review was undertaken to see if there was a connection between bleeding disorders specially platelet aggregation defect and endometriosis. This association was explored in animal models as well as in clinical studies suggesting that women with endometriosis have a higher rate of platelet aggregation defect. Deficiency of von Willebrand factor (VWF), a protein required for the normal adhesion of platelets to the site of injured endothelium may be associated with advanced stage of endometriosis on laparoscopy. The present review concludes that platelets may be a culprit in the development of endometriosis and that platelet aggregation were seen in endometriotic lesions.

Abstract (croatian)

Posljednjih nekoliko desetljeća bilježimo veliki napredak u liječenju ginekoloških poremećaja i opstetričke skrbi u žena sa poremećajima koagulacije. Unatoč tome ostaje niz nerazriješenih pitanja u ovom području. Niz opservacijskih studija provedeno je radi rasvjetljavanja ove problematike s glavnim ciljem poboljšanja skrbi o bolesnicama. Nedavne studije pokazale su da trombociti igraju važnu ulogu u razvoju endometrioze. Cilj ovog preglednog rada bio je istražiti postoji li povezanost između između poremećaja koagulacije, posebice poremećaja agregacije trombocita i endometrioze. Ova je povezanost istraživana na životinjskim modelima kao i u kliničkim studijama koje ukazuju da žene s endometriozom imaju veću učestalost poremećaja agregacije trombocita. Manjak von Willebrandovog faktora (vWF), proteina potrebnog za normalno prianjanje trombocita na mjesto ozlijeđenog endotela, povezan je s višim stupnjem endometrioze dijagnosticiranim
laparoskopski. Zaključak ovog preglednog rada je da trombociti mogu biti odgovorni za razvoj endometrioze odnosno da je poremećaj u agregaciji trombocita nađen u endometriotskim lezijama.

• Keywords: platelet aggregation; endometriosis; bleeding disorders; platelet function disorder; von Willebrand factor
• Keywords (croatian): agregacija trombocita; endometrioza; poremećaji krvarenja; poremećaji trombocita; von Willebrand faktor
• Language: english
• URN:NBN: urn:nbn:hr:105:461318
• Study programme: Title: Medicine (in English language); Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-10-08 08:14:41