SGLT-2 inhibitors for the treatment of type-2 diabetes in heart failure patients

master's thesis

• Title (croatian): Inhibitori SGLT-2 u liječenju bolesnika sa šećernom bolešću tip 2 i zatajivanjem srca
• Author: Daren Anthony Redguard
• Mentor: Matias Trbušić (mentor)
• Committee member: Matias Trbušić (predsjednik povjerenstva)
• Committee member: Vjekoslav Radeljić (član povjerenstva)
• Committee member: Boško Skorić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2020-07-17, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract

In this literature review we have summarised the types of Sglt-2 inhibitors for the treatment of type-2 diabetes, their mechanism of action, possible interaction with other treatment options, the existing management guidelines and the results of the clinical trials, and the major cardiovascular and renal adverse events. In addition, we have focused on the effects of Sglt-2 inhibitors in heart failure patients. As the literature review requires a careful analysis of the quality and the quantity of research findings, we have tried to gather a wide range of information from the scientific databases to find evidence-based material. For this purpose, a systematic search of the available literature was performed (6). Prior to the literature search keyword selection was performed to include as wide range of articles as possible. The relevant literature has been screened from the very beginning of digitalizing of the articles up to May 2, 2020. The selection of the articles was based on the screening of the article title and the abstract. The search was limited to English results only. After that the databases for the systematic search where selected. The Medline (PubMed) and Embase were chosen as the most relevant, based on the research question and the coverage.

Abstract (croatian)

U ovom smo pregledu literature saželi vrste inhibitora Sglt-2 za liječenje dijabetesa tipa 2, njihov mehanizam djelovanja, moguću interakciju s drugim metodama liječenja, postojeće smjernice za zbrinjavanje te rezultate kliničkih ispitivanja i glavne štetne učinke na kardiovaskularni sustav i bubrege. Osim toga, usredočili smo se na učinke inhibitora Sglt-2 na bolesnike sa zatajenjem srca. Budući da pregled literature zahtijeva pažljivu analizu kvalitete i količinu rezultata istraživanja, pokušali smo prikupiti širok raspon informacija iz znanstvenih baza podataka kako bismo pronašli materijal koji se temelji na dokazima. U tu svrhu izvršeno je sustavno pretraživanje dostupne literature (6). Prije pretraživanja literature izvršen je izbor ključnih riječi kako bi se uključio što širi spektar članaka. Relevantna literatura pregledavana je od samog početka digitalizacije članaka do 2. svibnja 2020. Odabir članaka temeljio se na pregledavanju naslova članka i sažetka. Pretraživanje je bilo ograničeno samo na rezultate na engleskom jeziku. Nakon toga su baze podataka za sustavnu pretragu bile odabrane. Medline (PubMed) i Embase odabrani su kao najrelevantniji, na temelju istraživačkog pitanja i pokrića.

• Keywords: SGLT-2 inhibitor; type-2 diabetes; heart failure; cardiovascular risk
• Keywords (croatian): inhibitor SGLT-2; dijabetes tipa 2; zatajenje srca; kardiovaskularni rizik
• Language: english
• URN:NBN: urn:nbn:hr:105:332245
• Study programme: Title: Medicine (in English language); Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-10-08 08:27:58