Hormonal correlates of acne and hirsutism

master's thesis

• Author: Iva Trgovčić
• Mentor: Dinka Pavičić-Baldani (mentor)
• Committee member: Zrinka Bukvić Mokos (predsjednik povjerenstva)
• Committee member: Dinka Pavičić-Baldani (član povjerenstva)
• Committee member: Lana Škrgatić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2014-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Gynecology and Obstetrics

Abstract

Clinical traits associated with androgens, acne and hirsutism, are important
diagnostic features of polycystic ovary syndrome (PCOS). Current data suggests that the
majority of patients with hirsutism, between 75-85%, and between 20-40% of patients
with persistent acne only, have PCOs. Androgens are one of the determining elements
in the development of acne due to the influence of two major factors in acne
pathogenesis: enhanced follicular keratosis and increased sebum production.
Even though excess androgen levels play a significant role in the manifestation of
acne, in PCOS patients, the degree of severity cannot be linearly associated with serum
androgen levels. Their levels, should not, therefore be used in determining the dosage of
anti-androgen therapy. In the PCOS patient, the significant negative correlation
observed between serum SHBG levels and the degree of hirsutism, gives rise to the fact
that hormonal contraception, which increases SHBG levels, should be the therapy of
choice in treating the PCOS patient.

• Keywords: acne; hirsutism; androgens
• Language: english
• URN:NBN: urn:nbn:hr:105:911124
• Study programme: Title: Medicine (in English language); Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2015-12-03 13:48:19