Von Willebrand Factor, Factor VIII, and Other Acute Phase Reactants as Biomarkers of Inflammation and Endothelial Dysfunction in Chronic Graft-Versus-Host Disease

Scientific paper - Review paper

• Author: Antonela Lelas
• Author: Hildegard Theresia Greinix
• Author: Daniel Wolff
• Author: Günther Eissner
• Author: Steven Živko Pavletić
• Author: Dražen Pulanić
• Author's institution: University of Zagreb; School of Medicine; (Department of Internal Medicine)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract (english)

Chronic graft-versus-host disease (cGvHD) is an immune mediated late complication of allogeneic hematopoietic stem cell transplantation (alloHSCT). Discovery of adequate biomarkers could identify high-risk patients and provide an effective pre-emptive intervention or early modification of therapeutic strategy, thus reducing prevalence and severity of the disease among long-term survivors of alloHSCT. Inflammation, endothelial injury, and endothelial dysfunction are involved in cGvHD development. Altered levels of acute phase reactants have shown a strong correlation with the activity of several immune mediated disorders and are routinely used in clinical practice. Since elevated von Willebrand factor (VWF) and factor VIII (FVIII) levels have been described as acute phase reactants that may indicate endothelial dysfunction and inflammation in different settings, including chronic autoimmune diseases, they could serve as potential candidate biomarkers of cGvHD. In this review we focused on reported data regarding VWF and FVIII as well as other markers of inflammation and endothelial dysfunction, evaluating their potential role in cGvHD.

• Keywords (english): Acute-Phase Proteins / metabolism*; Biomarkers / blood; Chronic Disease; Endothelial Cells / metabolism*; Endothelium, Vascular / metabolism*; Factor VIII / metabolism*; Graft vs Host Disease / blood*; Graft vs Host Disease / etiology; Graft vs Host Disease / immunology; Hematopoietic Stem Cell Transplantation / adverse effects; Hemostasis / immunology; Humans; Inflammation / blood; Transplantation, Homologous / adverse effects; von Willebrand Factor / metabolism*
• Language: english
• Publication type: Scientific paper - Review paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Frontiers in Immunology
• Numbering: vol. 12, 676756
• e-ISSN: 1664-3224
• DOI: https://doi.org/10.3389/fimmu.2021.676756
• URN:NBN: urn:nbn:hr:105:528505
• Publication: 2021-04-30
• Document URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.676756/full
• Type of resource: Text
• Access conditions: Open access
• Created on: 2021-11-04 09:31:21