prikaz prve stranice dokumenta AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review
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Scientific paper - Original scientific paper
AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review
Cells, 10 (2021), 5; 1095. https://doi.org/10.3390/cells10051095
Višnjić, Dora; Lalić, Hrvoje; Dembitz, Vilma; Tomić, Barbara; Smoljo, Tomislav

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Višnjić, D., Lalić, H., Dembitz, V., Tomić, B. & Smoljo, T. (2021). AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review. Cells, 10. (5). doi: 10.3390/cells10051095

Višnjić, Dora, et al. "AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review." Cells, vol. 10, no. 5, 2021. https://doi.org/10.3390/cells10051095

Višnjić, Dora, Hrvoje Lalić, Vilma Dembitz, Barbara Tomić and Tomislav Smoljo. "AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review." Cells 10, no. 5 (2021). https://doi.org/10.3390/cells10051095

Višnjić, D., et al. (2021) 'AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review', Cells, 10(5). doi: 10.3390/cells10051095

Višnjić D, Lalić H, Dembitz V, Tomić B, Smoljo T. AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review. Cells [Internet]. 2021 May 04 [cited 2024 December 24];10(5). doi: 10.3390/cells10051095

D. Višnjić, H. Lalić, V. Dembitz, B. Tomić and T. Smoljo, "AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review", Cells, vol. 10, no. 5, May 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:140315. [Accessed: 24 December 2024]

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Metadata
Title (english)AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review
AuthorDora Višnjić
AuthorHrvoje Lalić
AuthorVilma Dembitz
AuthorBarbara Tomić
AuthorTomislav Smoljo
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Physiology and Immunology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Physiology
Abstract (english)
5-Aminoimidazole-4-carboxamide ribonucleoside (AICAr) has been one of the most commonly used pharmacological modulators of AMPK activity. The majority of early studies on the role of AMPK, both in the physiological regulation of metabolism and in cancer pathogenesis, were based solely on the use of AICAr as an AMPK-activator. Even with more complex models of AMPK downregulation and knockout being introduced, AICAr remained a regular starting point for many studies focusing on AMPK biology. However, there is an increasing number of studies showing that numerous AICAr effects, previously attributed to AMPK activation, are in fact AMPK-independent. This review aims to give an overview of the present knowledge on AMPK-dependent and AMPK-independent effects of AICAr on metabolism, hypoxia, exercise, nucleotide synthesis, and cancer, calling for caution in the interpretation of AICAr-based studies in the context of understanding AMPK signaling pathway.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCells
Numberingvol. 10, no. 5, 1095
e-ISSN2073-4409
DOIhttps://doi.org/10.3390/cells10051095
URN:NBNurn:nbn:hr:105:140315
Publication2021-05-04
Document URLhttps://www.mdpi.com/2073-4409/10/5/1095
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2021-11-08 10:22:38