prikaz prve stranice dokumenta The Onset of Systemic Oxidative Stress Associated with the Accumulation of Lipid Peroxidation Product Acrolein in the Skin of Patients with Small-Vessel Vasculitis
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Scientific paper - Original scientific paper
The Onset of Systemic Oxidative Stress Associated with the Accumulation of Lipid Peroxidation Product Acrolein in the Skin of Patients with Small-Vessel Vasculitis
Molecules, 26 (2021), 8; 2344. https://doi.org/10.3390/molecules26082344
Sredoja Tišma, Vesna; Bulimbašić, Stela; Galešić Ljubanović, Danica; Galešić, Krešimir; Morović-Vergles, Jadranka; Mitrović, Joško; Uchida, Koji; Tatzber, Franz; Žarković, Neven; Jaganjac, Morana

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Sredoja Tišma, V., Bulimbašić, S., Galešić Ljubanović, D., Galešić, K., Morović Vergles, J., Mitrović, J. ... Jaganjac, M. (2021). The Onset of Systemic Oxidative Stress Associated with the Accumulation of Lipid Peroxidation Product Acrolein in the Skin of Patients with Small-Vessel Vasculitis. Molecules, 26. (8). doi: 10.3390/molecules26082344

Sredoja Tišma, Vesna, et al. "The Onset of Systemic Oxidative Stress Associated with the Accumulation of Lipid Peroxidation Product Acrolein in the Skin of Patients with Small-Vessel Vasculitis." Molecules, vol. 26, no. 8, 2021. https://doi.org/10.3390/molecules26082344

Sredoja Tišma, Vesna, Stela Bulimbašić, Danica Galešić Ljubanović, Krešimir Galešić, Jadranka Morović Vergles, Joško Mitrović, Koji Uchida, Franz Tatzber, Neven Žarković and Morana Jaganjac. "The Onset of Systemic Oxidative Stress Associated with the Accumulation of Lipid Peroxidation Product Acrolein in the Skin of Patients with Small-Vessel Vasculitis." Molecules 26, no. 8 (2021). https://doi.org/10.3390/molecules26082344

Sredoja Tišma, V., et al. (2021) 'The Onset of Systemic Oxidative Stress Associated with the Accumulation of Lipid Peroxidation Product Acrolein in the Skin of Patients with Small-Vessel Vasculitis', Molecules, 26(8). doi: 10.3390/molecules26082344

Sredoja Tišma V, Bulimbašić S, Galešić Ljubanović D, Galešić K, Morović Vergles J, Mitrović J, and sur.. The Onset of Systemic Oxidative Stress Associated with the Accumulation of Lipid Peroxidation Product Acrolein in the Skin of Patients with Small-Vessel Vasculitis. Molecules [Internet]. 2021 April 17 [cited 2024 November 22];26(8). doi: 10.3390/molecules26082344

V. Sredoja Tišma, et al., "The Onset of Systemic Oxidative Stress Associated with the Accumulation of Lipid Peroxidation Product Acrolein in the Skin of Patients with Small-Vessel Vasculitis", Molecules, vol. 26, no. 8, April 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:602676. [Accessed: 22 November 2024]

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Metadata
Title (english)The Onset of Systemic Oxidative Stress Associated with the Accumulation of Lipid Peroxidation Product Acrolein in the Skin of Patients with Small-Vessel Vasculitis
AuthorVesna Sredoja Tišma
AuthorStela Bulimbašić
AuthorDanica Galešić Ljubanović
AuthorKrešimir Galešić
AuthorJadranka Morović-Vergles
AuthorJoško Mitrović
AuthorKoji Uchida
AuthorFranz Tatzber
AuthorNeven Žarković
AuthorMorana Jaganjac
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pathology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Abstract (english)
Small-vessel vasculitis (SVV) is the inflammation of the vessel wall that can result in hemorrhage and/or ischemia. Among the histological findings in SVV are increased infiltrating neutrophils, which, due to their oxidative burst and myeloperoxidase activity, release excessive reactive oxygen species, triggering a chain reaction of lipid peroxidation and yielding reactive aldehydes such as acrolein. The implication of oxidative stress in the pathogenesis of SVV was studied, focusing on acrolein immunohistochemistry in the affected skin vessels and systemic stress response. Samples from SVV patients and healthy subjects were collected and analyzed for total serum peroxides, total antioxidant capacity, inflammatory and immunological parameters, as well as for the presence of acrolein–protein adducts in the skin tissue specimens. The obtained data showed that systemic redox homeostasis and iron metabolism are altered in SVV patients. Possible biomarkers in the evaluation of oxidative status, disease activity and prevalence were indicated. Furthermore, a strong correlation between the accumulation of acrolein–protein adducts in the skin and the progression of the disease was revealed. Thus, the results of this study demonstrate that SVV is not only associated with systemic oxidative stress but also with tissue-specific oxidative stress that promotes acrolein formation and protein modification correlating with the severity of cutaneous vasculitis.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMolecules
Numberingvol. 26, no. 8, 2344
e-ISSN1420-3049
DOIhttps://doi.org/10.3390/molecules26082344
URN:NBNurn:nbn:hr:105:602676
Publication2021-04-17
Document URLhttps://www.mdpi.com/1420-3049/26/8/2344
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2021-11-11 09:54:02