Međudjelovanje konstitucijskih značajki i čimbenika rizika radnoga okoliša na incidenciju profesionalnoga kontaktnoga dermatitisa u frizerskih učenika tijekom školovanja

doctoral thesis

• Title (english): Interaction of constitutional and occupational risk factors on the incidence of occupational contact dermatitis in hairdressing apprentices during vocational training
• Author: Zrinka Franić
• Mentor: Suzana Ljubojević Hadžavdić (mentor)
• Mentor: Jelena Macan (komentor)
• Committee member: Romana Čeović (predsjednik povjerenstva)
• Committee member: Jadranka Sertić (član povjerenstva)
• Committee member: Jadranka Mustajbegović (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2021-09-24, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Public Health and Health Care; Occupational and Sports Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Dermatovenerology
• Universal decimal classification (UDC): 614 - Public health and hygiene. Accident prevention

Abstract

Cilj istraživanja bio je utvrditi povezanost konstitucijskih značajki pojedinca i čimbenika rizika radnoga okoliša koji utječu na pojavu i tijek profesionalnoga kontaktnoga dermatitisa (PKD) u frizerskih učenika.
U istraživanje je uključeno 408 frizerskih učenika iz 25 gradova u Republici Hrvatskoj koji su ispitani na početku školovanja i praćeni u 3 faze na kraju svake školske godine. Protokol istraživanja uključivao je upitnike s pitanjima o samoprijavljenim simptomima dermatitisa šaka i atopije te radnim uvjetima, kliničku evaluaciju kožnih promjena pomoću Osnabrueck Hand Eczema Severity Index-a (OHSI), genotipizaciju polimorfizama gena za filagrin (FLG), mjerenje transepidermalnog gubitka vode (TEWL) i pH kože te epikutano testiranje učenika s kožnim promjenama koje su trajale 3 mjeseca ili dulje.
Stopa incidencije PKD-a iznosila je 32,3/100 osoba po godini, dok je ukupna trogodišnja prevalencija PKD-a bila 50,3%. Samo jedna učenica imala je mutaciju gena za FLG te ove mutacije nisu utvrđene rizičnim čimbenikom nastanka PKD-a. Na početku školovanja 45,73% učenika prijavilo je postojanje atopijskih bolesti, a njih 7,38% atopijski dermatitis (AD). Kod 71,4% učenika s pozitivnom reakcijom na epikutanom testiranju utvrđena je kontaktna senzibilizacija na profesionalne alergene već tijekom školovanja za frizersko zanimanje. Dokazani čimbenici rizika za nastanak PKD-a na početku školovanja su: AD, postojanje kožnih promjena i viši pH kože nadlanica. Porast TEWL-a nadlanica veći od 5 g/m2/h mogao bi imati prediktivnu vrijednost za pojavu PKD-a tijekom školovanja. Uočeno je da učenici nedostatno koriste zaštitne rukavice prilikom obavljanja rizičnih frizerskih radnji. Sve navedeno ukazuje na potrebu za poboljšanjem preventivnih pregleda učenika te pojačanom edukacijom o pravilnoj zaštiti kože na radu.

Abstract (english)

The aim of this study was to determine the relationship between the constitutional characteristics of the individual and occupational risk factors that affect the occurrence and course of occupational contact dermatitis (OCD) in hairdressing apprentices.
The research included 408 hairdressing apprentices from 25 towns in the Republic of Croatia who were examined at the beginning of education and monitored in 3 phases at the end of each school year. The study protocol included questionnaires with questions on self-reported symptoms of hand dermatitis, atopy and working conditions, clinical evaluation of skin changes using the Osnabrueck Hand Eczema Severity Index (OHSI), genotyping of filaggrin (FLG) gene polymorphisms, transepidermal water loss (TEWL) and skin pH measurement and patch testing of students with skin changes lasting 3 months or longer.
The OCD incidence rate was 32.3/100 persons per year, while the total three-year prevalence of OCD was 50.3%. Only one student had a mutation of the FLG gene, therefore these mutations were not identified as a risk factor for OCD. At the beginning of education, 45.73% of apprentices reported the existence of atopic diseases, and 7.38% of them atopic dermatitis (AD). In 71.4% of apprentices with a positive reaction to patch testing, contact allergy to occupational allergens was established already during training for the hairdressing profession. Proven risk factors for the development of OCD at the beginning of education were: AD, presence of skin changes and higher hand skin pH. An increase in hand TEWL greater than 5 g/m2/ h could have a predictive value for the occurrence of OCD during schooling. It was noticed that students did not use protective gloves often enough when performing risky hairdressing activities. All of the above indicates the need to improve preventive examinations of apprentices and education on proper skin protection at work.

• Keywords: profesionalni kontaktni dermatitis; frizerski učenici; polimorfizmi gena za filagrin; pH kože; transepidermalni gubitak vode; epikutano testiranje
• Keywords (english): occupational contact dermatitis; hairdressing apprentices; filaggrin gene polymorphisms; skin pH; transepidermal water loss; patch testing
• Language: croatian
• URN:NBN: urn:nbn:hr:105:936837
• Study programme: Title: Biomedicine and Health Sciences; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
• Type of resource: Text
• Extent: 143 str.
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-12-14 10:17:34