Unos joda i funkcija štitnjače u dojilja i dojenčadi na području grada Zagreba

doctoral thesis

• Title (english): Iodine status and thyroid function in lactating women and infants - survey in the City of Zagreb
• Author: Marina Prpić
• Mentor: Maja Franceschi (mentor)
• Committee member: Dražen Huić (predsjednik povjerenstva)
• Committee member: Darko Kaštelan (član povjerenstva)
• Committee member: Miroslav Dumić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2021-10-22, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Oncology
• Universal decimal classification (UDC): 616 - Pathology. Clinical medicine

Abstract

Uvod: Dojilje i dojenčad imaju povećane zahtjeve za unos joda pa su pod rizikom nedostatnog unosa joda. Cilj rada: Cilj istraživanja bio je ispitati unos joda i funkciju štitnjače u dojilja i njihove dojenčadi. ----- Metode: Istraživanje je obuhvatilo 116 dojilja i 116 novorođenčadi i dojenčadi s područja Grada Zagreba, koji su tvorili parove. U svih ispitanika izmjerena je koncentracija joda u urinu (UIC) i parametri funkcije štitnjače (TSH, T4, Tg) iz krvi, dok je u dojilja dodatno određena koncentracija joda u majčinu mlijeku (BMIC). Dodatno su prikupljeni podatci o unosu hrane koja sadrži jod i sol. ------ Rezultati: Prema rezultatima istraživanja 99,2 % dojilja koristilo je jodiranu kuhinjsku sol, a 12,9 % vitamine i minerale s jodom u trenutku ispitivanja. Medijan (IQR) UIC iznosio je u dojilja 84, 5 μg/L (26,0 – 149,7 μg/L), a u dojenčadi 231,0 μg/L (153,0-351,5 μg/L). Medijan (IQR) BMIC iznosio je 122 μg/L (88,0 – 184,0 μg/L). Nađena je statistički značajna pozitivna korelacija između BMIC i UIC u novorođenčadi i dojenčadi (p < 0.001). Također je utvrđena pozitivna povezanost parametara funkcije štitnjače u dojilja i novorođenčadi i dojenčadi. ----- Zaključak: Ovo je prvo istraživanje u Hrvatskoj koje pokazuje da je mjerenje BMIC pouzdan pokazatelj unosa joda u dojilja i da predviđa unos joda u dojenčadi. Istraživanje potvrđuje da program univerzalnog jodiranja soli s 25 mg KI/kg soli u Hrvatskoj osigurava dostatan unos joda u dojilja i dojenčadi.

Abstract (english)

Background: Lactating women (LW) and infants have high dietary iodine requirements and they are at risk for iodine deficiency.-----
Aims: The aim is to assess iodine status and thyroid function in LW and their breastfed infants in Zagreb, Croatia.
Methods: The study included 116 LW and 166 breastfed infant pairs from the City of Zagreb. Urinary iodine concentration (UIC) and thyroid function parameters (TSH, T4, Tg) from the blood were measured in all subjects, while iodine concentration in breast milk (BMIC) was additionally determined in LW. Additionally, data on the intake of foods containing iodine and salt were collected. -----
Results: Survey analysis indicated that 99,2% of the LW used iodized salt in household and 12,9% used iodine containing vitamin and mineral supplements at the time of the research.
The median (IQR) of UIC was 84, 5 μg/L (26,0-149,7 μg/L) in LW and 231,2 μg/L (153,0-351,5 μg/L) in infants, whereas BMIC was 122 μg/L (88,0- 184,0 μg/L).
A statistically significant positive correlation between BMIC and infants UIC (p < 0.001) as well as between LW and the infants’ thyroid function parameters were observed. -----
Conclusion: This is the first study in Croatia demonstrating that BMIC is a reliable biomarker of iodine status during lactation and could predicts iodine intake in infants.
The study confirms that mandatory salt iodization with 25 mg KI/ kg of salt in Croatia ensures sufficient dietary iodine for LW and optimal iodine nutrition for breastfed infants through breast milk.

• Keywords: dojenje; dojenčad; tireoglobulin; hormoni štitnjače; koncentracija joda u majčinom mlijeku; koncentracija joda u urinu
• Keywords (english): breast feeding; infants; thyroglobulin; thyroid hormones; breast milk iodine concentration; urinary iodine concentration
• Language: croatian
• URN:NBN: urn:nbn:hr:105:767550
• Study programme: Title: Biomedicine and Health Sciences; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
• Type of resource: Text
• Extent: 72 str.
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-12-16 08:18:09