Increasing colorectal cancer incidence in individuals aged <50 years – a population-based study

master's thesis

• Title (croatian): Porast incidencije raka debelog crijeva kod osoba <50 godina – populacijska studija
• Author: Ida Gutlic
• Mentor: Goran Augustin (mentor)
• Committee member: Goran Augustin (predsjednik povjerenstva)
• Committee member: Ivan Dobrić (član povjerenstva)
• Committee member: Tomislav Meštrović (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Surgery); Zagreb
• Defense date and country: 2021-07-16, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Surgery
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Oncology

Abstract

PURPOSE: Data on the incidence of colorectal cancer (CRC) is conflicting, and it is unknown if the incidence is constant, declining, or increasing. Proximal colon cancer is considered to be more common among older individuals, but recent data have shown that rectal cancer and distal colon cancer have been increasing in the younger population. The aim of this study was to determine the trends regarding CRC incidence and tumour location in Sweden. ----- METHODS: CRC statistics from the National Board of Health and Welfare 1995–2015 were used. CRC incidence rates by age group (<50 years, 50–79 years, ≥80 years), sex, and tumour localisation (proximal colon, distal colon, or rectum) were calculated and analysed using Poisson regression. ----- RESULTS: The age-standardised incidence of CRC increased in Sweden during the study period. This increase was significant (P<0.0001) for colon cancer during the study period for all age groups regardless of tumour localisation. The greatest increase (27–52% per decade) in the colon cancer incidence rate was seen among men and women <50 years of age. The incidence rate for rectal cancer increased for men <50 years (P<0.0001), decreased for both men and women aged ≥80 years (P<0.005), and did not change for the remaining groups. ----- CONCLUSIONS: The CRC incidence in Sweden, in particular colon cancer, is increasing regardless of tumour localisation for individuals <50 years of age. This paper supports the implementation of population-based colorectal cancer screening. A diagnostic workup should be performed in symptomatic individuals <50 years of age.

Abstract (croatian)

SVRHA: Podaci o incidenciji kolorektalnog raka su proturiječni i nije poznato je li incidencija konstantna, opadajuća ili rastuća. Rak proksimalnog debelog crijeva smatra se češćim među starijim osobama ali nedavni podaci pokazuju da se rak stražnjeg debelog crijeva i rak distalnog debelog crijeva povećavaju u mlađoj populaciji. Svrha ovog istraživanja je bila odrediti trendove što se tiče incidencije kolorektalnog raka i lokacije tumora u Švedskoj. ----- METODE: Korišteni su statistički podaci kolorektalnog raka iz Naciolnalnog ministarstva za zdravlje i socijalnu skrb 1995-2015. Stopa incidencije kolorektalnog raka prema dobnoj skupini (<50 godina, 50-79 godina, ≥80 godina), spolu i lokaciji tumora (proksimalno debelo crijevo, distalno debelo crijevo ili stražnje debelo crijevo) su izračunati i analizirani pomoću Poissonove regresije. ----- REZULTATI: Dobna standardizirana incidencija kolorektalnog raka povećala se u Švedskoj tijekom razdoblja istraživanja. Ovaj porast bio je signifikantan (P<0.0001) za rak debelog crijeva tijekom istraživanog razdoblja za sve dobne skupine bez obzira na lokaciju tumora. Najveći porast (27-52% /desetljeće) stope incidencije raka debelog crijeva viđen je među muškarcima i ženama mlađim od 50 godina. Stopa incidencije raka stražnjeg debelog crijeva porasla je za muškarce <50 godina (P<0.0001), smanjila se i za muškarce i za žene u dobi ≥80 godina (P<0.005) i nije se promijenila za preostale skupine. ----- ZAKLJUČAK: Incidencija kolorektalnog raka u Švedskoj, posebno raka debelog crijeva, raste bez obzira na lokaciju tumora za osobe mlađe od 50 godina. Ova studija podržava uvođenje populacijski baziranog probira za kolorektalni rak. Diagnostičku obradu treba vršiti kod simptomatskih osoba mlađih od 50 godina.

• Keywords: colorectal cancer; incidence; Sweden; screening
• Keywords (english): kolorektalni rak; incidencija; Švedska; probir
• Language: english
• URN:NBN: urn:nbn:hr:105:166590
• Study programme: Title: Medicine (in English language); Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-12-21 09:45:16