Spolne razlike u riziku i prevenciji tromboembolijskih događaja u bolesnika s fibrilacijom atrija

master's thesis

• Title (english): Gender differences in risk and prevention of thromboembolic events in patients with atrial fibrillation
• Author: Klara Barišić
• Mentor: Diana Delić-Brkljačić (mentor)
• Committee member: Nikola Bulj (predsjednik povjerenstva)
• Committee member: Martina Lovrić Benčić (član povjerenstva)
• Committee member: Diana Delić-Brkljačić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2021-07-16, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract

Fibrilacija atrija (FA) najčešća je aritmija u svijetu te je povezana s povećanim rizikom za tromboembolijske događaje (TD). Adekvatna antikoagulantna terapija je nužna u prevenciji istih, no ona često izostaje stvarajući tako prepreku u terapijskom pristupu za sve kliničare. Posebno su uočljive razlike među spolovima, s obzirom da se ženski spol prepoznaje kao nezavisan faktor rizika za TD. Također, više autora navodi kako je kod žena i prevencija TD lošija u odnosu na muškarce, tj. da su u manjem broju adekvatno antikoagulirane. Cilj ovog istraživanje je pokazati postoje li razlike u riziku i prevenciji TD kod muškaraca i žena koji imaju dijagnozu FA. U istraživanju je sudjelovalo 387 osoba, od kojih je 325 imalo indikaciju za antikoagulantnu terapiju. Bolesnici su podijeljeni na adekvatno i neadekvatno antikoagulirane. Svi podaci dobiveni su anamnestički, a svakom bolesniku je izračunati CHA2DS2Vasc i HAS-BLED broj. Prevalencija adekvatno antikoaguliranih muškaraca i žena je gotovo jednaka i ne nalaze se statistički značajne razlike te je ona niska (žene 36,7%, muškarci 32%). Na temelju CHA2DS2Vasc i HAS-BLED broja utvrđene su statistički značajne razlike među spolovima. Žene imaju povećani rizik za TD od muškaraca što može biti povezano s ženskim spolom kao faktorom rizika te njihovom većom životnom dobi. Muškarci imaju veći rizik od krvarenja.

Abstract (english)

Atrial fibrillation is the most common arithmya worldwide and it is linked with higher risk for thromboembolic events. Adequate anticoagulation is necessary for the prevention but in most of the cases there is a lack of it which creates a problem for the clinicians. The difference between genders can be seen, with female gender being independent risk factor for thromboembolic events. Also more authors state that prevention of thromboembolic events is worse in women than in men. The goal of this study is to show if there are differences in risk and prevention of thromboembolic events in men and women who have atrial fibrillation. This study included 387 patients of which 325 had the indication for anticoagulation. Patients were divided on those who have adequate anticoagulation and those who don't. All informations were collected from patient's history and every patient has had its CHA2DS2Vasc and HAS-BLED score callculated. Prevalences of adequate anticoagulated men and women were the same and there are no statisticly relevant difference (36,7% women, 32% men). Prevalence is low. Differences between genders when it comes to CHA2DS2Vasc and HAS-BLED score are statisticly relevant . Women have a higher risk for thromboembolic events which can be associated with female gender being independent risk factor or with their higher age. Men generally have a higher risk for bleeding.

• Keywords: fibrilacija atrija; spol; tromboembolijski događaji; antikoagulantna terapija; rizik; prevencija
• Keywords (english): atrial fibrillation; gender; thromboembolic event; anticoagulation; risk; prevention
• Language: croatian
• URN:NBN: urn:nbn:hr:105:139820
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-01-21 08:00:19