Uloga hiperbarične oksigenoterapije (HBOT) u liječenju oboljelih od COVID-19

Scientific paper - Review paper

• Title (english): The role of hyperbaric oxygenotherapy (HBOT) in the treatment of COVID-19 patients
• Author: Sead Žiga
• Author: Dejan Andrić
• Author: Sanja Jurić Banai
• Author: Kristina Franjić
• Author: Dragan Vujović
• Author: Eva Pleško
• Author: Dživo Ljubičić
• Author: Nevenka Piskač Živković
• Author: Marko Banić
• Author's institution: University of Zagreb; School of Medicine; (Department of Internal Medicine)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract (croatian)

Pandemija COVID-19 postavila je velik izazov suvremenoj medicini. Unatoč značajnim naporima medicinske i znanstvene zajednice, do trenutka pisanja ovog članka i dalje ne postoji ciljano etiološko liječenje bolesnika akutno oboljelih od COVID-19, kao i bolesnika s post-COVID sindromom. Hiperbarična oksigenoterapija (HBOT) jest medicinski i znanstveno priznat terapijski postupak u liječenju brojnih akutnih i kroničnih stanja u kojima je nedostatak kisika osnovni patofiziološki poremećaj. S obzirom na nekoliko publiciranih serija slučajeva koji su pokazali značajan povoljni učinak primjene HBOT-a u liječenju pacijenata oboljelih od infekcije COVID-19 te na osnovi višedesetljetnog iskustva u primjeni HBOT-a u drugim poljima, rodila se potreba za provođenjem kvalitetnih i dobro strukturiranih studija kojima je cilj jasno ispitati utjecaj primjene HBOT-a u liječenju oboljelih od COVID-19. Prema dostupnim izvorima trenutno se u svijetu provodi 9 takvih istraživanja. Mehanizmi učinka primjene HBOT-a u liječenju oboljelih od COVID-19 zasnivaju se na korekciji hipoksije, atenuaciji upalnog odgovora te „otplate duga kisika“ u kratkom vremenskom razdoblju, na taj način osiguravajući prozor aerobnom metabolizmu u duboko hipoksičnim tkivima i važnim organima.

Abstract (english)

The COVID-19 pandemic has posed a major challenge to modern medicine. Despite significant efforts by the medical and scientific community, at the time of writing, there is still no targeted etiological treatment for acutely ill COVID-19 patients as well as patients with post-COVID syndrome. Hyperbaric oxygen therapy (HBOT) is a medically and scientifically recognized therapeutic procedure in the treatment of a number of acute and chronic conditions in which oxygen deficiency is pathophysiologically primary disorder. Given the several published series of cases that have shown a significant beneficial effect of HBOT in the treatment of patients with COVID-19 infection, and based on decades of experience in the use of HBOT in other fields, the need to conduct quality and well-structured studies arose with the aim to clearly examine the impact of HBOT use in the treatment
of COVID-19 patients. According to available sources, nine such studies are being conducted worldwide.The mechanisms of the effect of HBOT in the treatment of COVID-19 patients are based on the correction of hypoxia, attenuation of the inflammatory response and “repayment of oxygen debt” in a short period of time, thus providing a window to aerobic metabolism in deeply hypoxic tissues and important organs.

• Keywords (croatian): COVID-19 – komplikacije, liječenje; HIPERBARIČNA OKSIGENOTERAPIJA; VIRUSNA PNEUMONIJA – liječenje; HIPOKSIJA; ISHOD LIJEČENJA; SARS-COV-2; PANDEMIJA
• Keywords (english): COVID-19 – complications, therapy; HYPERBARIC OXYGENATION; PNEUMONIA, VIRAL therapy; HYPOXIA; TREATMENT OUTCOME; SARS-CoV-2, PANDEMICS
• Language: croatian
• Language: english
• Publication type: Scientific paper - Review paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Liječnički vjesnik
• Numbering: vol. 143, no. 11-12, pp. 473-477
• p-ISSN: 0024-3477
• e-ISSN: 1849-2177
• DOI: https://doi.org/10.26800/LV-143-11-12-9
• URN:NBN: urn:nbn:hr:105:567727
• Publication: 2021
• Document URL: https://hrcak.srce.hr/269404
• Type of resource: Text
• Access conditions: Open access
• Created on: 2022-01-27 12:33:45