prikaz prve stranice dokumenta Two-dimensional shear wave elastography predicts survival in advanced chronic liver disease
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Scientific paper - Original scientific paper
Two-dimensional shear wave elastography predicts survival in advanced chronic liver disease
Gut, 71 (2022), 2; 402-414. https://doi.org/10.1136/gutjnl-2020-323419
Trebicka, Jonel; Gu, Wenyi; de Ledinghen, Victor; Aubé, Christophe; Krag, Aleksander; Praktiknjo, Michael; Castera, Laurent; Dumortier, Jerome; Bauer, David Josef Maria; Friedrich-Rust, Mireen; Pol, Stanislas; Grgurević, Ivica; Zheng, Rongqin; Francque, Sven; Gottfriedovà, Halima; Mustapić, Sanda; Sporea, Ioan; Berzigotti, Annalisa; Uschner, Frank Erhard; Simbrunner, Benedikt; Ronot, Maxime; Cassinotto, Christophe; Kjaergaard, Maria; Andrade, Filipe; Schulz, Martin; Semmler, Georg; Tješić Drinković, Ida; Chang, Johannes; Brol, Maximilian Joseph; Rautou, Pierre Emmanuel; Vanwolleghem, Thomas; Strassburg, Christian P; Boursier, Jerome; Ferstl, Philip Georg; Rasmussen, Ditlev Nytoft; Reiberger, Thomas; Vilgrain, Valerie; Guibal, Aymeric; Guillaud, Olivier; Zeuzem, Stefan; Vassord, Camille; Lu, Xue; Vonghia, Luisa; Senkerikova, Renata; Popescu, Alina; Margini, Cristina; Wang, Wenping; Thiele, Maja; Jansen, Chrisitan More authors...

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Trebicka, J., Gu, W., de Ledinghen, V., Aubé, C., Krag, A., Praktiknjo, M. ... Jansen, C. (2022). Two-dimensional shear wave elastography predicts survival in advanced chronic liver disease. Gut, 71. (2), 402-414. doi: 10.1136/gutjnl-2020-323419

Trebicka, Jonel, et al. "Two-dimensional shear wave elastography predicts survival in advanced chronic liver disease." Gut, vol. 71, no. 2, 2022, pp. 402-414. https://doi.org/10.1136/gutjnl-2020-323419

Trebicka, Jonel, Wenyi Gu, Victor de Ledinghen, Christophe Aubé, Aleksander Krag, Michael Praktiknjo, Laurent Castera, et al. "Two-dimensional shear wave elastography predicts survival in advanced chronic liver disease." Gut 71, no. 2 (2022): 402-414. https://doi.org/10.1136/gutjnl-2020-323419

Trebicka, J., et al. (2022) 'Two-dimensional shear wave elastography predicts survival in advanced chronic liver disease', Gut, 71(2), pp. 402-414. doi: 10.1136/gutjnl-2020-323419

Trebicka J, Gu W, de Ledinghen V, Aubé C, Krag A, Praktiknjo M, and sur.. Two-dimensional shear wave elastography predicts survival in advanced chronic liver disease. Gut [Internet]. 2022 February [cited 2024 December 23];71(2):402-414. doi: 10.1136/gutjnl-2020-323419

J. Trebicka, et al., "Two-dimensional shear wave elastography predicts survival in advanced chronic liver disease", Gut, vol. 71, no. 2, pp. 402-414, February 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:485163. [Accessed: 23 December 2024]

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Title (english)Two-dimensional shear wave elastography predicts survival in advanced chronic liver disease
AuthorJonel Trebicka
AuthorWenyi Gu
AuthorVictor de Ledinghen
AuthorChristophe Aubé
AuthorAleksander Krag
AuthorMichael Praktiknjo
AuthorLaurent Castera
AuthorJerome Dumortier
AuthorDavid Josef Maria Bauer
AuthorMireen Friedrich-Rust
AuthorStanislas Pol
AuthorIvica Grgurević
AuthorRongqin Zheng
AuthorSven Francque
AuthorHalima Gottfriedovà
AuthorSanda Mustapić
AuthorIoan Sporea
AuthorAnnalisa Berzigotti
AuthorFrank Erhard Uschner
AuthorBenedikt Simbrunner
AuthorMaxime Ronot
AuthorChristophe Cassinotto
AuthorMaria Kjaergaard
AuthorFilipe Andrade
AuthorMartin Schulz
AuthorGeorg Semmler
AuthorIda Tješić Drinković
AuthorJohannes Chang
AuthorMaximilian Joseph Brol
AuthorPierre Emmanuel Rautou
AuthorThomas Vanwolleghem
AuthorChristian P Strassburg
AuthorJerome Boursier
AuthorPhilip Georg Ferstl
AuthorDitlev Nytoft Rasmussen
AuthorThomas Reiberger
AuthorValerie Vilgrain
AuthorAymeric Guibal
AuthorOlivier Guillaud
AuthorStefan Zeuzem
AuthorCamille Vassord
AuthorXue Lu
AuthorLuisa Vonghia
AuthorRenata Senkerikova
AuthorAlina Popescu
AuthorCristina Margini
AuthorWenping Wang
AuthorMaja Thiele
AuthorChrisitan Jansen
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Internal Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Objective: Liver stiffness measurement (LSM) is a tool used to screen for significant fibrosis and portal hypertension. The aim of this retrospective multicentre study was to develop an easy tool using LSM for clinical outcomes in advanced chronic liver disease (ACLD) patients. ----- Design: This international multicentre cohort study included a derivation ACLD patient cohort with valid two-dimensional shear wave elastography (2D-SWE) results. Clinical and laboratory parameters at baseline and during follow-up were recorded. LSM by transient elastography (TE) was also recorded if available. The primary outcome was overall mortality. The secondary outcome was the development of first/further decompensation. ----- Results: After screening 2148 patients (16 centres), 1827 patients (55 years, 62.4% men) were included in the 2D-SWE cohort, with median liver SWE (L-SWE) 11.8 kPa and a model for end stage liver disease (MELD) score of 8. Combination of MELD score and L-SWE predict independently of mortality (AUC 0.8). L-SWE cut-off at ≥20 kPa combined with MELD ≥10 could stratify the risk of mortality and first/further decompensation in ACLD patients. The 2-year mortality and decompensation rates were 36.9% and 61.8%, respectively, in the 305 (18.3%) high-risk patients (with L-SWE ≥20 kPa and MELD ≥10), while in the 944 (56.6%) low-risk patients, these were 1.1% and 3.5%, respectively. Importantly, this M10LS20 algorithm was validated by TE-based LSM and in an additional cohort of 119 patients with valid point shear SWE-LSM. ----- Conclusion: The M10LS20 algorithm allows risk stratification of patients with ACLD. Patients with L-SWE ≥20 kPa and MELD ≥10 should be followed closely and receive intensified care, while patients with low risk may be managed at longer intervals.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleGut
Numberingvol. 71, no. 2, pp. 402-414
p-ISSN0017-5749
e-ISSN1468-3288
DOIhttps://doi.org/10.1136/gutjnl-2020-323419
URN:NBNurn:nbn:hr:105:485163
Publication2022-02
Document URLhttps://gut.bmj.com/lookup/doi/10.1136/gutjnl-2020-323419
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2022-02-08 08:28:20