Učestalost i značajke operativno odstranjenih tumora nadbubrežne žlijezde u KBC-u Zagreb od 2011. – 2016. godine

professional thesis

• Title (english): The incidency and characteristics of surgically treated adrenal tumors in UHC Zagreb from 2011 to 2016
• Author: Dijana Knežević Strinavić
• Mentor: Tina Dušek (mentor)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2021-07-09, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract

Uvod: Tumori nadbubrežne žlijezde najčešće su nefunkcionalni dobroćudni tumori koji ne metastaziraju i ne invadiraju okolna tkiva. Međutim, tumori veći od 4 cm koji su nehomogenog prikaza na radiološkim snimkama (CT, MR) mogu biti i maligne naravi. Takve tumore kao i one koji luče neki od homona, potrebno je operativno liječiti. -----
Cilj: Cilj rada je istražiti kliničke, hormonske, radiološke i histološke karakteristike svih tumora nadbubrežne žlijezde koji su operativno liječeni u KBC-u Zagreb od siječnja 2011. do prosinca 2016. godine. -----
Ispitanici i metode: Radi se o retrospektivnom istraživanju u koje su uključeni svi bolesnici stariji od 18 godina koji su operirani zbog tumora nadbubrežne žlijezde u navedenom razdoblju. Podatke smo dobili iz medicinske dokumentacije te iz baze podataka bolesnika s tumorima nadbubrežne žlijezde koja postoji u Zavodu za endokrinologiju KBC Zagreb. -----
Rezultati: u navedenom razdoblju operativno je liječeno ukupno 200 bolesnika, 131 žena i 69 muškaraca. Prosječna veličina operiranih tumora je 57 mm u muškaraca i 45 mm u žena. Najveći broj bolesnika je imao patohistološku dijagnozu adenoma (N=78), potom feokromocitoma (N=31) i adrenokortikalnog karcinoma (N=23). Najveći broj bolesnika je imao kliničku sliku nefunkcionalnog tumora (N=84), potom subkliničkog Cushingovog sindroma (N=42), feokromocitoma (N=34), Cushingovog sindroma (N=22), primarnog hiperaldosteronizma (N=11) i Cushingove bolesti (N=2). -----
Zaključak: Svi pacijenti s verificiranim tumorom nadbubrežne žlijezde trebaju proći hormonsku evaluaciju i potrebno je isključiti malignitet. Osim hormonske sekrecije, posebnu pozornost treba obratiti na radiološke karakteristike.

Abstract (english)

Introduction: Adrenal tumors are in the most of cases benign tumors which do not metastasize or invade nearby tissue. But in case of size >4 cm and inhomogenous density on CT/MR scan they can indicate malignancy. This kind of tumors and also tumors which can overproduct some of the endocrine hormons should be threated surgically. -----
Aim: Aim is to analize clinical, hormonal, radiologic and histologic characteristics of all surgically treated adrenal tumors in UHC Zagreb in the period of January 2011 until December 2016. -----
Objects and methods: It is a retrospective study. The study will include all patients who have had surgery for adrenal tumor in UHC Zagreb in 5 years period. Characteristics of patients we found out from medical documentation and from a database of patients that exists in the Department of Endocrinology, UHC Zagreb. -----
Results: A total of 200 patients were operated during this period, 131 women and 69 men. The average size of tumors was 57 mm in men, and 45 mm in women. The largest number of patients have had a patohistological diagnosis of adenoma (N=78), then pheochromocytoma (N=31) and adrenocortical carcinoma (N=23). The largest number of patients presented with tumors which had not overproduct any of endocrine hormons (N=84), then subclinical Cushing's syndrome (N=42), pheochromocytoma (N=34), Cushing's syndrome (N=22), primary hyperaldosteronismus (N=11) and Cushing's disease (N=2). -----
Conclusion: All patients with finding of adrenal tumor should undergo hormon evaluation and it is necessary to exclude malignancy. Except of hormon secretion, attention should be focused also on radiological characteristics.

• Keywords: adenom nadbubrežne žlijezde; subklinički Cushingov sindrom; feokromocitom; adrenokortikalni karcinom
• Keywords (english): adrenal adenoma; subclinical Cushing’s syndrome; pheochromocytoma; adrenocortical carcinoma
• Language: croatian
• URN:NBN: urn:nbn:hr:105:301926
• Study programme: Title: Internal medicine; Study programme type: university; Study level: postgraduate specialist; Academic / professional title: sveučilišni/a magistar/magistra opće interne medicine (sveučilišni/a magistar/magistra opće interne medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-02-24 10:00:37