Title Uloga vitamina D u postupcima pomognute oplodnje Title (english) The role of vitamin D in assisted reproduction technology Author Petra Klanac Mentor Marina Šprem Goldštajn (mentor)Committee member Lana Škrgatić (predsjednik povjerenstva)Committee member Dinka Pavičić Baldani (član povjerenstva)Committee member Marina Šprem Goldštajn (član povjerenstva)Granter University of Zagreb Defense date and country 2021-07-16, Croatia Scientific / art field, BIOMEDICINE AND HEALTHCARE Abstract Vitamin D je steroidni hormon topiv u mastima čija glavna uloga je održavanje ravnoteže kalcija i fosfata u organizmu. No, u novije vrijeme su receptori i enzimi metabolizma vitamina D otkriveni i u drugim tkivima tako i reproduktivnom sustavu muškarca i žene. Pronađeni su u granulosa stanicama, endometriju i promotorskim regijama nekih gena. In vivo istraživanja na životinjama i in vitro istraživanja na ljudskim stanicama su pokazala da vitamin D ima ulogu u regulaciji folikulogeneze, lučenja spolnih hormona, lučenja AMH i placentacije, kao i imunomodulatornu ulogu u endometriju. Ta saznanja i podatci da čak do 40% žena reproduktivne dobi ima manjak vitamina D, a taj postotak se kod žena sa sindromom policističnih jajnika penje do 80%, su naveli znanstvenike da ispitaju benefite vitamina D u praksi, tj. kliničkim istraživanjima, kao jeftine i široko dostupne terapije. Cilj kliničkih istraživanja je bio ispitati može li vitamin D poboljšati ishode postupaka potpomognute oplodnje u žena koje prolaze te postupke, odvojeno žena sa sindromom policističnih jajnika ili onih s endometriozom ili svih žena koje prolaze postupak potpomognute oplodnje bez obzira na uzrok. Dosadašnja istraživanja nisu uspjela utvrditi benefite vitamina D na ishode postupaka potpomognute oplodnje ni za jednu od navedenih grupa, s napomenom da su dosadašnje znanje i istraživanja nedostatni za konačan zaključak. Receptori su pronađeni i u spermijima, Leydigovim i Sertolijevim stanicama, a dokazi iz in vivo istraživanja na životinjama i in vitro istraživanja na ljudskim stanicama pokazuju da vitamin D poboljšava pokretnost, volumen i broj spermija, kao i to da može regulirati lučenje testosterona. No, rezultati kliničkih istraživanja su kontradiktorni, a konačni zaključak o ulozi vitamina D u muškoj plodnosti i ishodima postupaka pomognute oplodnje nije moguće donijeti bez daljnjih istraživanja.
Abstract (english) Vitamin D is a fat-soluble steroid hormone whose main role is calcium and phosphates homeostasis. However, lately Vitamin D receptors and Vitamin D metabolizing enzymes have been found in other tissues including male and female reproductive tissue. They have been located in granulosa cells, endometrium and promoter regions of genes involved in reproduction. In vivo studies on animals and In vitro studies on human cells have shown that Vitamin D has a role in folliculogenesis regulation, sex hormone and AMH secretion regulation, placentation, as well as immunomodulatory role in endometrium. Those information, as well as some studies showing up to 40% of reproductive age women are Vitamin D insufficient, that figure going up to 80% in women with polycystic ovary syndrome, have made scientists research possible benefits of Vitamin D in clinical practice, as an affordable and widely accessible therapy. The aim of those clinical trials was to establish whether Vitamin D can improve assisted reproduction technologies outcomes. Some of those clinical trials included all women going through assisted reproduction technology procedures, some only women with polycystic ovary syndrome and some only women with endometriosis. So far, researchers couldn't find any benefits of Vitamin D on assisted reproduction technology procedure outcomes in any of the researched groups of women. However, all the researchers remarked that current clinical trials are not sufficient to make a final conclusion regarding the role of Vitamin D in assisted reproduction technology in women. On the other side, Vitamin D receptors and metabolism enzymes have also been located in spermatozoa, Leydig and Sertoli cells. In vivo studies on animals and In vitro studies on human cells have shown that Vitamin D can increase sperm mobility, volume and count, as well as regulate testosterone secretion. But, the results of clinical trials are contradictory and a final conclusion on the role of Vitamin D in male fertility and assisted reproduction technology outcomes cannot be made without further research.
Keywords
vitamin D
postupci pomognute oplodnje
AMH
endometrioza
sindrom policističnih jajnika
Keywords (english)
vitamin D
assisted reproduction technology
AMH
endometriosis
polycystic ovary syndrome
Language croatian URN:NBN urn:nbn:hr:105:455935 Study programme Title: Medicine Type of resource Text File origin Born digital Access conditions Open access Terms of use Created on 2022-02-24 10:48:45
