Pemphigu - The Crux of Clinics, Research, and Treatment during the COVID-19 Pandemic

Scientific paper - Review paper

• Author: Branka Marinović
• Author: Joško Miše
• Author: Ines Lakoš Jukić
• Author: Zrinka Bukvić Mokos
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Dermatovenerology

Abstract (english)

Pemphigus is a rare autoimmune disease characterised by the production of pathogenic autoantibodies in response to different desmosome proteins. The pathophysiological process leads to the development of blisters and erosions on mucosal and/or skin surfaces. The classical clinical variants of pemphigus are pemphigus vulgaris and pemphigus foliaceus. A diagnostic delay is very common in pemphigus, especially among patients with mucosal involvement. However, in recent years we have witnessed considerably fewer patients with extensive mucocutaneous manifestations, since patients with oral lesions are referred to dermatologists to start the treatment much sooner than they had been previously. Among non-classical variants of pemphigus, unusual cases with discrepancies between autoantibody profiles and clinics challenge the “desmoglein compensation theory”. The identification of several other autoantigens that perform a role in the pathogenesis of different variants of pemphigus will progress immunodermatology towards an approach that will determine personalized pemphigus subtypes for each patient. Comorbidities among patients are primarily associated with the prolonged use of corticosteroids and other immunosuppressive agents. The SARS-CoV-2 pandemic raised concerns regarding the immunosuppressive effects of treatment and the risk of a more complicated COVID-19 infection, as well as on the ability to develop an adequate vaccine response.

• Keywords (english): COVID-19; SARS-CoV-2; desmoglein; immunodermatology; pemphigus; rituximab
• Language: english
• Publication type: Scientific paper - Review paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Biomedicines
• Numbering: vol. 9, no. 11, 1555
• e-ISSN: 2227-9059
• DOI: https://doi.org/10.3390/biomedicines9111555
• URN:NBN: urn:nbn:hr:105:415295
• Publication: 2021-10-28
• Document URL: https://www.mdpi.com/2227-9059/9/11/1555
• Type of resource: Text
• Access conditions: Open access
• Created on: 2022-03-07 08:13:48