Invertni papilom paranazalnih sinusa

master's thesis

• Title (english): Inverted papilloma of paranasal sinuses
• Author: Ivan Mesar
• Mentor: Mario Bilić (mentor)
• Committee member: Srećko Branica (predsjednik povjerenstva)
• Committee member: Mihael Ries (član povjerenstva)
• Committee member: Mario Bilić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Othorhinolaryngology and Head and Neck Surgery); Zagreb
• Defense date and country: 2021-07-16, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Otorhinolaryngology

Abstract

Invertni papilom paranazalnih sinusa je benigna neoplazma sinusa. To je benigni tumor koji se pojavljuje u 0,5 – 4% tumora u regiji nosa. Incidencija sinonazalnih papiloma u općoj populaaciji se kreće između 0.74 do 1.5 novodijagnosticiranih tumora na 100,000 ljudi godišnje. 80% od svih dijagnosticiranih papiloma nosa su invertni papilomi. Etiologija sinonazalnih papiloma je još uvijek nepoznata. Tumor se širi na agresivan način u stražnjoj nosnoj šupljini i paranazalnim sinusima. Kada se tumor širi lokalno uništava okolna tkiva (kosti, hrskavice) i ima tendenciju da recidivira na mjestu gdje je odstranjen. Invertni papilom paranazalnih sinusa u 5 – 10% slučajeva može maligno alterirati i tako nastane planocelularni karcinom. Najčešći simptimi bolesti koji se javljaju su jednostrana opstrukcija i sekrecija iz nosa. Papilomi se dijagnosticiraju tijekom endoskopskog pregleda nosa tijekom čega se uzme i uzorak tumora za analizu. CT i MR pretrage su vrlo korisne pri određivanju proširenosti tumorske tvorbe. Operacijski zahvat je osnovni način liječenja koji se koristi za liječenje sinonazalnih papiloma. Postoje tri osnovna tipa zahvata koji se koriste u ovim slučajevima. Vanjski operativni pristupi (lateralna rinotomija), endoskopski pristup i kombinirani pristup su često korištene tehnike. Endoskopska kirurgija je metoda izbora jer su brojne studije dokazale da je stopa recidiva jednaka u odnosu na druga dva prihvaćena pristupa. Ukupni postotak recidiva invertnog papiloma nakon kirurškog zahvata je oko 30%.

Abstract (english)

Inverted papilloma of paranasal sinuses is a benign neoplasm of the sinuses. It is a benign sinonasal tumor that occurs in 0,5 – 4% of all tumors in the region. The incidence of sinonasal papilloma in general population ranges from 0.74 to 1.5 people diagnosed per 100,000 per year. 80% of all papilloma of the region are inverted papilloma. The origin of sinonasal papilloma is still unknown. It spreads aggressively in the rear nasal cavity and sinuses. When it spreads locally, it destroys surrounding tissues (bone, cartilage) and has tendency to recur in the region. Inverted papilloma in 5 – 10% of cases can become more malignant squamous cell carcinoma. Most prevalent symptoms of this disease are unilateral nasal obstruction and rhinorrhea.
Papilloma is diagnosed with endoscope examination during which the tumor tissue sample is taken. CT or MRI scan are very useful to determine the extent of the tumor. Surgery is the main therapeutical procedure that is used to cure sinonasal papilloma. There are three main types of surgical procedures that are used in this case. Open approach surgery (lateral rhinotomy), endoscopic surgery and combined procedure are techniques that are prevalent. Endoscopic surgery is a method of choice because it has the same recurrence rate compared with the other two accepted methods. The overall recurrence of inverted papilloma after surgical procedure is about 30%.

• Keywords: papilom; paranazalni sinusi; invertni papilom; benigni; tumor; operacija
• Keywords (english): papilloma; paranasal sinuses; inverted papilloma; benign; tumor; surgery
• Language: croatian
• URN:NBN: urn:nbn:hr:105:796652
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-03-11 11:39:03