Povezanost psihijatrijskih poremećaja i metabolizma nezasićenih masnih kiselina

master's thesis

• Title (english): The association of psychiatric disorders and metabolism of unsaturated fatty acids
• Author: Ivana Mihaljević
• Mentor: Ivančica Delaš (mentor)
• Committee member: Slavica Potočki (predsjednik povjerenstva)
• Committee member: Dragana Fabris (član povjerenstva)
• Committee member: Ivančica Delaš (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Medical Chemistry, Biochemistry and Clinical Chemistry); Zagreb
• Defense date and country: 2021-09-11, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Basic Medical Sciences; Medical Biochemistry
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Clinical Biochemistry
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Psychiatry

Abstract

Tijekom prošlog stoljeća dramatično se u ljudskoj prehrani smanjio unos n-3 višestruko nezasićenih masnih kiselina (engl. PUFA), a istovremeno se povećala incidencija različitih psihijatrijskih poremećaja. Procjenjuje se da u suvremenoj prehrani omjer n-6:n-3 PUFA iznosi 20:1. To pokazuje da suvremena prehrana nije zadovoljavajuća zbog toga što bi omjer n-6:n-3 PUFA u prehrani trebao biti 4:1 kako bi se postigli svi pozitivni učinci za očuvanje zdravlja. Još se 80-ih godina prošlog stoljeća javila ideja da psihijatrijski poremećaji mogu biti posljedica nedostatka n-3 višestruko nezasićenih masnih kiselina. Zbog povećanja učestalosti psihijatrijskih poremećaja i ograničene učinkovitosti dostupnih lijekova, kao i čestih neželjenih nuspojava, postoji potreba za novim metodama liječenja. Posljednjih godina povećan je interes za istraživanje povezanosti psihijatrijskih poremećaja i višestruko nezasićenih masnih kiselina. Otkrivene su različite promjene statusa n-6 i n-3 PUFA u različitim psihijatrijskim poremećajima te predloženi brojni mehanizmi kojima bi ove kiseline mogle utjecati na pojavu psihijatrijskih poremećaja. Mnogo je istraživanja pokazalo pozitivan učinak suplementacije n-3 višestruko nezasićenih masnih kiselina na prevenciju psihijatrijskih bolesti i njihove simptome. Međutim, rezultati tih istraživanja nisu konkluzivni pa je potrebno provesti daljnja istraživanja kako bi se utvrdili točni mehanizmi povezanosti psihijatrijskih poremećaja i metabolizma nezasićenih masnih kiselina te predložili protokoli liječenja primjenom n-3 PUFA kojima bi se poboljšala klinička slika te potencijalno prevenirali mnogi psihijatrijski poremećaji.

Abstract (english)

Over the past century, the intake of n-3 polyunsaturated fatty acids (PUFA) in the human diet has dramatically decreased and at the same time the incidence of various psychiatric disorders has increased. It is estimated that the n-6:n-3 ratio of polyunsaturated fatty acids in modern diet is 20:1. This shows that modern diet is not adequate because the n-6:n-3 PUFA ratio in the diet should be 4:1 to achieve all positive health effects. In the 1980s, the idea emerged that psychiatric disorders could be the result of a deficiency of n-3 polyunsaturated fatty acids. Due to the increased incidence of psychiatric disorders and the limited effectiveness of available medications, as well as frequent side effects, there exists a need for new treatments. In recent years, there has been a growing interest in researching the association between psychiatric disorders and polyunsaturated fatty acids. Various changes in the n-6 and n-3 PUFA status in various psychiatric disorders have been discovered, and a number of mechanisms have been proposed by which these acids could influence the appearance of psychiatric disorders. Many studies have shown a positive effect of n-3 polyunsaturated fatty acid supplementation on the prevention of psychiatric illnesses and their symptoms. However, the results of these studies are not conclusive, so further research is needed to determine the exact mechanisms of association between psychiatric disorders and unsaturated fatty acid metabolism and to propose treatment protocols for n-3 polyunsaturated fatty acids that could improve clinical picture and potentially prevent many psychiatric disorders.

• Keywords: psihijatrijski poremećaji; n-3 višestruko nezasićene masne kiseline; PUFA; suplementacija; središnji živčani sustav
• Keywords (english): psychiatric disorders; n-3 polyunsaturated fatty acids; supplementation; PUFA; central nervous system
• Language: croatian
• URN:NBN: urn:nbn:hr:105:520472
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-03-11 11:59:06