Utjecaj hormonske kontracepcije na promjene raspoloženja

master's thesis

• Title (english): Influence of hormonal contraception on mood changes
• Author: Ivana Popić
• Mentor: Tatjana Pavelić Turudić (mentor)
• Committee member: Vladimir Blagaić (predsjednik povjerenstva)
• Committee member: Dinka Pavičić Baldani (član povjerenstva)
• Committee member: Tatjana Pavelić Turudić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Gynecology and Obstetrics); Zagreb
• Defense date and country: 2021-09-02, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Gynecology and Obstetrics

Abstract

Dinamične promjene koncentracija spolnih hormona tijekom svakog menstrualnog ciklusa uzrokuju, u velikog broja žena, pojavu barem jednog fizičkog i/ili psihološkog simptoma nekoliko dana prije pojave krvarenja. Također, sve rasprostranjenija uporaba oralne hormonske kontracepcije zbog reproduktivnih, ali i brojnih drugih ne-kontraceptivnih razloga, pobudila je interes znanstvenika za otkrivanjem mehanizama kojim prirodni i sintetski spolni hormoni utječu na raspoloženje i emocionalno stanje. Cilj ovog rada je dati pregled dosadašnjih otkrića o utjecaju egzogenih spolnih hormona, s naglaskom na oralnu hormonsku kontracepciju (OHK), na zbivanja u središnjem živčanom sustavu koja dovode do poboljšanja i pogoršanja raspoloženja u zdravih žena i žena s predmenstrualnim poremećajima raspoloženja (PMS-om i PMDD-om). Na početku je kratak pregled centralnih učinaka estrogena, progesterona i neurosteroida. Potom slijedi prikaz rezultata brojnih studija, koje uspoređuju zdrave i zahvaćene žene, a na kojima počivaju teorije o mehanizmima nastanka predmenstrualnih poremećaja raspoloženja. Posljednje poglavlje opisuje djelovanje OHK na raspoloženje ističući farmakološke karakteristike OHK te individualna obilježja svake korisnice, što u kombinaciji utječe na poboljšanje odnosno pogoršanje raspoloženja.

Abstract (english)

Due to the dynamic changes in the concentration of sex hormones during the menstrual cycle, a large number of women experience at least some sort of physical and / or psychological symptoms a few days before the onset of bleeding. Also, the increasing use of oral hormonal contraception for reproductive and many other non-contraceptive reasons, has prompted scientists to study and analyze the mechanisms by which natural and synthetic sex hormones affect mood and emotional state. The aim of this paper is to provide an overview of previous findings on the influence of exogenous sex hormones, with an emphasis on combined oral contraceptives (COCs) on processes in the central nervous system that either improve or worsen mood among healthy women and women with premenstrual mood disorders (PMS and PMDD). The paper begins with a brief overview of the central effects of estrogen, progesterone and neurosteroids. Furthermore, that is followed by the presentation of the results of numerous studies, which compare healthy and affected women and which serve as a basis for the theories on the mechanisms of premenstrual mood disorders. The last chapter describes the effects of COCs on mood, emphasizing the pharmacological characteristics of COCs and the individual characteristics of each user, which, in combination, affect the improvement or deterioration of mood.

• Keywords: spolni hormoni; neurosteroidi; predmenstrualni poremećaji; oralna hormonska kontracepcija; raspoloženje
• Keywords (english): sex hormones; neurosteroids; premenstrual disorders; combined oral contraceptives; mood
• Language: croatian
• URN:NBN: urn:nbn:hr:105:135785
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-04-08 10:41:36