Primjena hiperbarične terapije kisikom u ortopediji

master's thesis

• Title (english): Use of hyperbaric oxygen therapy in orthopaedics
• Author: Ivan Putica
• Mentor: Tomislav Smoljanović (mentor)
• Committee member: Ivan Bojanić (predsjednik povjerenstva)
• Committee member: Tomislav Đapić (član povjerenstva)
• Committee member: Tomislav Smoljanović (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Orthopedics); Zagreb
• Defense date and country: 2021-09-11, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Orthopedics

Abstract

Hiperbarična terapija kisikom (engl. hyperbaric oxygen therapy (HBOT)) je tretman koji uključuje udisanje 100% kisika u okruženju pod pritiskom. Kad se pacijentu daje 100% kisika pod povećanim pritiskom, hemoglobin na sebe veže maksimalnu količinu kisika, a krv se dodatno hiperoksigenira otapanjem kisika u plazmi. Razlikujemo jednomjesne i višemjesne komore. Dok se u jednomjesnoj komori u određenom razdoblju HBOT-om liječi samo jedan pacijent, u višemjesnim komorama odjednom se može liječiti više pacijenata. HBOT povećava oksigenaciju na staničnoj razini, pospješuje stanični oporavak, povećava broj matičnih stanica, pojačava neovaskularizaciju, poboljšava protok krvi, ubija bakterije, čime doprinosi liječenju infekcije u kostima i mekim tkivima te ubrzava cijeljenje mekotkivnih ozljeda i rana. Zbog svojih ljekovitih i baktericidnih učinaka HBOT se koristi kao adjuvantna terapija u nekoliko ortopedskih stanja kao što su primjerice: prolazna osteoporoza kuka, avaskularna nekroza glave femura, refraktorni osteomijelitis, crush ozljeda, kompartment sindrom i poremećeno koštano cijeljenje. Cilj ovog rada je pregled trenutne literature o tim stanjima te prikaz potencijalnih budućih indikacija za HBOT u ortopediji kao što su oštećenja zglobne hrskavice te sportske i mekotkivne ozljede.

Abstract (english)

Hyperbaric oxygen therapy (HBOT) is a treatment that involves breathing 100% oxygen in a pressurized environment. When a patient is given 100% oxygen, haemoglobin is saturated and the blood is hyperoxygenated by dissolving oxygen within the plasma. Patients can be treated in multiplace or monoplace chambers. Multiplace chambers treat multiple patients at the same time with an inside attendant that supervises patients. Monoplace chambers compress one patient at a time. HBOT increases oxygenation at cellular level, increases cellular recovery, increases stem cell count, enhances neovascularization, improves blood flow, kills bacteria and thus infections in bones and soft tissues, accelerates healing of soft tissue injuries and also wounds. In orthopaedics, HBOT is used as an adjuvant therapy because of its healing and bactericidal effects. HBOT has been shown to be useful in several orthopaedic conditions such as: transient osteoporosis of the hip, femoral head necrosis, refractory osteomyelitis, crush injury, compartment syndrome and impaired bone healing. The goal of this paper is to review the current literature on these conditions and presentation of potential future indications for HBOT in orthopaedics such as osteochondral defects and soft-tissue and sports injuries.

• Keywords: hiperbarična terapija kisikom; indikacije; ortopedija
• Keywords (english): hyperbaric oxygen therapy; indications; orthopaedics
• Language: croatian
• URN:NBN: urn:nbn:hr:105:356005
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-04-08 11:34:10