Evaluacija učinkovitosti stereotaktičke tjelesne radioterapije kod pacijenata s lokalno uznapredovalim karcinomom gušterače

master's thesis

• Title (english): Evaluation of the effectiveness of stereotactic body radiation therapy for locally advanced pancreatic cancer
• Author: Fran Rašić
• Mentor: Marko Sever (mentor)
• Committee member: Zvonko Zadro (predsjednik povjerenstva)
• Committee member: Tomislav Meštrović (član povjerenstva)
• Committee member: Marko Sever (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Surgery); Zagreb
• Defense date and country: 2021-07-16, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Surgery
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Radiotherapy and Oncology

Abstract

Karcinom gušterače je četvrti vodeći uzročnik smrtnosti kod pacijenata oboljelih od maligne bolesti s petogodišnjim preživljenjem od oko samo 5-6%. Jedino potencijalno kurabilno liječenje predstavlja radikalna kirurška resekcija. Stopa operabilnosti prilikom otkrivanja bolesti je samo 25%. Za pacijente s inoperabilnim karcinomom gušterače kao mogućnost liječenja nude se kemoterapija i radioterapija s relativno skromnim ukupnim preživljenjem. Rezultati sve većeg broja studija dovode u pitanje učinkovitost klasične radioterapije (CFTR). U posljednjih desetak godina sve više se spominje i koristi stereotaktička tjelesna radioterapija (SBRT) kao nova, obećavajuća terapija pacijenata s uznapredovalim karcinomom gušterače. Cilj naše studije je bio istražiti učinkovitost SBRT terapije. Retrospektivno smo analizirali pacijente koji su zbog lokalno uznapredovanog karcinoma gušterače liječeni SBRT terapijom. Analizirano je ukupno 26 pacijenata. Središnje ukupno preživljenje je bilo 15 mjeseci (raspon 5 - 22, IQR 11,00 - 17,25) uz 1 – godišnje preživljenje od 73.07% (19/26). Izračunati 6- i 12- mjesečni FFLP je bio 95,8% i 84,2%, a FFP za isto razdoblje je bio 73,1% i 53,8%. Pacijenti s tumorom lociranim u glavi gušterače imali su statistički značajno dulje preživljenje od pacijenata s tumorom lociranim u trupu ili repu gušterače. SBRT je učinkovita metoda s izvrsnom lokalnom kontrolom bolesti, uz prihvatljivu stopu komplikacija.

Abstract (english)

Pancreatic carcinoma is the fourth leading cause of mortality in patients with malignant disease with a 5 – year survival rate of only 5-6%. Radical surgical resection represents the only chance for a cure, but only 25% of patients are considered operable at the time of diagnosis. Chemotherapy and radiotherapy are offered as treatment modalities for patients with locally advanced pancreatic cancer with modest overall survival. In the last ten years stereotactic body radiation therapy (SBRT) has become a new, promising treatment modality. The aim of our study was to evaluate the effectiveness of SBRT. Retrospectively we analyzed 26 patients treated with SBRT due to diagnosed locally advanced pancreatic cancer. The median overall survival was 15 months (range 5 - 22, IQR 11,00 - 17,25) with a 1 – year overall survival of 73,07%. Six and twelve – months FFLP was 95,8% and 84,2% respectively. FFP for the same period was 73,1% and 53,8%. We also found that patients with a tumor located in the head of the pancreas had a statistically significant longer overall survival. SBRT is an effective method of treatment with great local tumor control and an acceptable rate of complications.

• Keywords: karcinom gušterače; radioterapija; preživljenje
• Keywords (english): pancreatic carcinoma; radiotherapy; survival
• Language: croatian
• URN:NBN: urn:nbn:hr:105:823589
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-05-04 11:59:28