Vrijednost bodovnog sustava u predskazivanju recidiva atrijske fibrilacije nakon krioizolacije plućnih vena

master's thesis

• Title (english): Validation of scoring systems in prognosis of atrial fibrillation recurrence post pulmonary vein isolation by cryoablation
• Author: Barbara Rubinić
• Mentor: Davor Puljević (mentor)
• Committee member: Boško Skorić (predsjednik povjerenstva)
• Committee member: Marko Jakopović (član povjerenstva)
• Committee member: Davor Puljević (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2021-07-16, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract

Fibrilacija atrija najčešća je aritmija. Liječenje fibrilacije atrija prema smjernicama Europskog kardiološkog društva sastoji se od antikoagulacije, bolje kontrole simptoma u vidu kontrole frekvencije i ritma te liječenja komorbiditeta. Osim medikamentne kontrole ritma, može se napraviti izolacija plućnih vena krioablacijom. Invazivni postupak nosi komplikacije poput paralize nervusa phrenicusa do srčane tamponade te je potrebno pacijente pravilno selektirati. U svrhu selekcije pacijenata u literaturi se navode mnogi bodovni sustavi koji predviđaju recidiv fibrilacije atrija nakon ablacije. Ciljevi ovog rada su ispitati kako recidiv fibrilacije atrija ovisi o bodovnim sustavima. Postavili smo hipotezu da modificirani CAAP-AF bodovni sustav najbolje previđa recidiv. U istraživanje je uključeno ukupno 350 pacijenata, od kojih je 75% muškaraca, a prosječna dob iznosi 58 godina. Statističkom analizom pokazano je da ukupni recidiv značajno ovisi o vrijednostima BASE-AF2, MB-LATER i modificiranom CAAP-AF bodovnom sustavu. BASE-AF2 i MB-LATER u svojim bodovnim sustavima sadrže varijablu ranog recidiva FA. Rezultati su u skladu s literaturom, a limitacije istraživanja su mali broj ispitanika te prethodna selekcija pacijenata za krioablaciju budući da se radi o retrospektivnom istraživanju. Zaključujemo kako je modificirani CAAP-AF bodovni sustav najprikladniji za selekciju pacijenata pogodnih za krioablaciju.

Abstract (english)

Atrial fibrillation is the most common arrhythmia. According to the European society of cardiology, treatment of atrial fibrillation consists of anticoagulation, better symptom control regarding control of the rhythm and heart rate and treatment of comorbidities. Apart from controlling the rhythm with drugs, it can also be controlled by pulmonary vein isolation by cryoablation. This invasive procedure has complications ranging from paralysis of nervus phrenicus to cardiac tamponade. Therefore, it is important to carefully select the patient for the procedure. Various scoring systems created to predict the atrial fibrillation recurrence are found in literature. The aim of this research is to examine how does atrial fibrillation recurrence depend on scoring systems. We hypothesized that modified CAAP-AF scoring system is the best in predicting the recurrence. 350 patients were included in the research with average age of 58 and 75% are male. Conducting the statistical analysis, we found that the total recurrence significantly depends on BASE-FA2, MB-LATER an modified CAAP-AF scoring systems. BASE-AF2 and MB-LATER account for the early atrial fibrillation recurrence. Results are in accordance with the literature. The limitations of our research lie in the small number of patients and the fact that patients were preselected because this is a retrospective research. In conclusion, modified CAAP-AF scoring system is the best for patient selection for cryoablation.

• Keywords: izolacija plućnih vena; krioablacija; fibrilacija atrija; recidiv fibrilacije atrija
• Keywords (english): atrial fibrillation; atrial fibrillation recurrence; cryoablation; pulmonary vein isolation
• Language: croatian
• URN:NBN: urn:nbn:hr:105:667432
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-05-05 12:08:41