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Scientific paper - Original scientific paper
Human DLG1 and SCRIB Are Distinctly Regulated Independently of HPV-16 during the Progression of Oropharyngeal Squamous Cell Carcinomas: A Preliminary Analysis
Cancers, 13 (2021), 17; 4461. https://doi.org/10.3390/cancers13174461
Lulić, Lucija; Jakovčević, Antonia; Manojlović, Luka; Dediol, Emil; Banks, Lawrence; Tomaić, Vjekoslav

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Lulić, L., Jakovčević, A., Manojlović, L., Dediol, E., Banks, L. & Tomaić, V. (2021). Human DLG1 and SCRIB Are Distinctly Regulated Independently of HPV-16 during the Progression of Oropharyngeal Squamous Cell Carcinomas: A Preliminary Analysis. Cancers, 13. (17). doi: 10.3390/cancers13174461

Lulić, Lucija, et al. "Human DLG1 and SCRIB Are Distinctly Regulated Independently of HPV-16 during the Progression of Oropharyngeal Squamous Cell Carcinomas: A Preliminary Analysis." Cancers, vol. 13, no. 17, 2021. https://doi.org/10.3390/cancers13174461

Lulić, Lucija, Antonia Jakovčević, Luka Manojlović, Emil Dediol, Lawrence Banks and Vjekoslav Tomaić. "Human DLG1 and SCRIB Are Distinctly Regulated Independently of HPV-16 during the Progression of Oropharyngeal Squamous Cell Carcinomas: A Preliminary Analysis." Cancers 13, no. 17 (2021). https://doi.org/10.3390/cancers13174461

Lulić, L., et al. (2021) 'Human DLG1 and SCRIB Are Distinctly Regulated Independently of HPV-16 during the Progression of Oropharyngeal Squamous Cell Carcinomas: A Preliminary Analysis', Cancers, 13(17). doi: 10.3390/cancers13174461

Lulić L, Jakovčević A, Manojlović L, Dediol E, Banks L, Tomaić V. Human DLG1 and SCRIB Are Distinctly Regulated Independently of HPV-16 during the Progression of Oropharyngeal Squamous Cell Carcinomas: A Preliminary Analysis. Cancers [Internet]. 2021 September 04 [cited 2024 December 19];13(17). doi: 10.3390/cancers13174461

L. Lulić, A. Jakovčević, L. Manojlović, E. Dediol, L. Banks and V. Tomaić, "Human DLG1 and SCRIB Are Distinctly Regulated Independently of HPV-16 during the Progression of Oropharyngeal Squamous Cell Carcinomas: A Preliminary Analysis", Cancers, vol. 13, no. 17, September 2021. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:181641. [Accessed: 19 December 2024]

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Title (english)Human DLG1 and SCRIB Are Distinctly Regulated Independently of HPV-16 during the Progression of Oropharyngeal Squamous Cell Carcinomas: A Preliminary Analysis
AuthorLucija Lulić
AuthorAntonia Jakovčević
AuthorLuka Manojlović
AuthorEmil Dediol
AuthorLawrence Banks
AuthorVjekoslav Tomaić
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Maxillofacial Surgery and Dentistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Surgery
Abstract (english)
The major causative agents of head and neck squamous cell carcinomas (HNSCCs) are either environmental factors, such as tobacco and alcohol consumption, or infection with oncogenic human papillomaviruses (HPVs). An important aspect of HPV-induced oncogenesis is the targeting by the E6 oncoprotein of PDZ domain-containing substrates for proteasomal destruction. Tumor suppressors DLG1 and SCRIB are two of the principal PDZ domain-containing E6 targets. Both have been shown to play critical roles in the regulation of cell growth and polarity and in maintaining the structural integrity of the epithelia. We investigated how modifications in the cellular localization and protein expression of DLG1 and SCRIB in HPV16-positive and HPV-negative histologic oropharyngeal squamous cell carcinomas (OPSCC) might reflect disease progression. HPV presence was determined by p16 staining and HPV genotyping. Whilst DLG1 expression levels did not differ markedly between HPV-negative and HPV16-positive OPSCCs, it appeared to be relocated from cell–cell contacts to the cytoplasm in most samples, regardless of HPV16 positivity. This indicates that alterations in DLG1 distribution could contribute to malignant progression in OPSCCs. Interestingly, SCRIB was also relocated from cell–cell contacts to the cytoplasm in the tumor samples in comparison with normal tissue, regardless of HPV16 status, but in addition there was an obvious reduction in SCRIB expression in higher grade tumors. Strikingly, loss of SCRIB was even more pronounced in HPV16-positive OPSCCs. These alterations in SCRIB levels may contribute to transformation and loss of tissue architecture in the process of carcinogenesis and could potentially serve as markers in the development of OPSCCs.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCancers
Numberingvol. 13, no. 17, 4461
e-ISSN2072-6694
DOIhttps://doi.org/10.3390/cancers13174461
URN:NBNurn:nbn:hr:105:181641
Publication2021-09-04
Document URLhttps://www.mdpi.com/2072-6694/13/17/4461
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-05-09 08:23:44