Doprinos smanjenog unosa kalija u etiopatogenezi arterijske hipertenzije

master's thesis

• Title (english): Contribution of reduced potassium intake in the etiopathogenesis of arterial hypertension
• Author: Maks Luka Šenjug
• Mentor: Zdenko Kovač (mentor)
• Committee member: Maja Sirotković Skerlev (predsjednik povjerenstva)
• Committee member: Jasenka Markeljević (član povjerenstva)
• Committee member: Zdenko Kovač (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Pathophysiology); Zagreb
• Defense date and country: 2021-09-25, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Pathophysiology

Abstract

Arterijska hipertenzija jedna je od najčešćih kroničnih bolesti, posljedica koje je veliko opterećenje zdravstvenih sustava diljem svijeta. Hipertenzija je multifaktorijalna bolest za koju su faktori rizika genetsko naslijeđe, okolišni čimbenici i rizična ponašanja. Uzrok hipertenzije najčešće se ne može otkriti (primarna hipertenzija), stoga se i dalje intenzivno istražuju načini kojima organizam održava krvni tlak. Lijekovi za liječenje hipertenzije smanjuju krvni tlak povećanjem gubitka vode i soli putem bubrega, širenjem krvnih žila ili usporavanjem srčanog rada. Opservacijska istraživanja su dugo pokazivala vezu između manje učestalosti hipertenzije i povećanog unosa kalija prehranom. U novije vrijeme su se počeli razmatrati i paleoantropološki dokazi o znatno većem unosu kalija u razdoblju prije razvoja poljoprivrede i prehrambene industrije. Osim smanjenog unosa kalija, današnja prehrana opterećena je i velikim unosom natrija (kuhinjska sol). Suvremena istraživanja, koja uključuju in vivo i randomizirane kliničke studije, pokazuju pozitivan učinak povećanja unosa kalija na visoki krvni tlak. Povećanje unosa kalija povećava gubitak soli i vode putem bubrega djelovanjem na prijenosnike za natrij i kalij.

Abstract (english)

Arterial hypertension is one of the most common non-communicable diseases, a source of a great number of healthcare expenses across the world. Hypertension is a multifactorial disease involving genetic and environmental risk factors and behavioural risks. Causes of hypertension are mostly unknown (primary hypertension) and therefore intensive research of blood pressure control mechanisms continues. Medications for treating hypertension reduce blood pressure by increasing salt and water loss through the kidneys, dilating blood vessels, or decreasing cardiac output. Observational studies have long been signalling a link between a lower incidence of hypertension and an increased intake of potassium in the diet. Recently research has started into paleoanthropological data regarding greater intake of potassium before the development of agriculture and food industry. Besides the reduced intake of potassium, the modern diet is very high in sodium (table salt). Current research, including in vivo and randomized clinical studies, show a beneficial effect of increased potassium intake on high blood pressure. Increasing potassium intake leads to an increase in salt and water loss through the kidneys by influencing sodium and potassium transporters.

• Keywords: nadoknada kalija; hipertenzija; natrij; prehrana
• Keywords (english): potassium supplementation; hypertension; sodium; diet
• Language: croatian
• URN:NBN: urn:nbn:hr:105:008840
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-05-12 08:46:35