Epizodni angioedem s eozinofilijom (Gleichov sindrom) – dijagnostički izazov

Scientific paper - Case study

• Title (english): Episodic angioedema with eosinophilia (Gleich syndrome) – a diagnostic challenge
• Author: Ana Marija Valetić
• Author: Joško Mitrović
• Author: Marija Jelušić
• Author: Branimir Anić
• Author: Jadranka Morović Vergles
• Author's institution: University of Zagreb; School of Medicine; (Department of Internal Medicine)
• Author's institution: University of Zagreb; School of Medicine; (Department of Pediatrics)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Pediatrics
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract (croatian)

Epizodni angioedem s eozinofilijom, poznat i kao Gleichov sindrom, izuzetno je rijedak poremećaj karakteriziran ponavljajućom pojavom angioedema, urtikarije, vrućice, porastom tjelesne težine, uz povišene serumske vrijednosti imunoglobulina M i leukocitozu sa značajnom eozinofilijom. Uzrok i patofiziološki mehanizmi nastanka bolesti nisu u potpunosti razjašnjeni. Javlja se većinom kod djece, odnosno odraslih osoba mlađe životne dobi. Prvi izbor u liječenju jesu glukokortikoidi, a prognoza je većinom dobra. U radu smo prikazali bolesnika kojemu smo na osnovi ponavljajućih epizoda angioedema i febriliteta uz prisustvo leukocitoze s eozinofilijom i povišenih vrijednosti imunoglobulina M postavili dijagnozu Gleichovog sindroma. Bolesnik je nakon primjene glukokortikoida tijekom četiri godine praćenja u stabilnoj remisiji bolesti.

Abstract (english)

Episodic angioedema with eosinophilia, also known as Gleich syndrome, is an extremely rare disorder characterized by recurrent occurrence of angioedema, urticaria, fever, increased body weight, elevated serum values of immunoglobulin M, and leukocytosis with significant eosinophilia. The cause and pathogenesis of the disease are not fully clarified. It occurs mostly in children or adults of younger age. The first choice of treatment are
glucocorticoids, and the prognosis is mostly good. We report a case of a patient who was diagnosed with Gleich syndrome based on recurrent episodes of angioedema and fever in the presence of leukocytosis with eosinophilia and elevated immunoglobulin M values. The patient has been in stabile remission for four years since the administration of glucocorticoids.

• Keywords (croatian): ANGIOEDEM – dijagnoza, farmakoterapja, komplikacije; EOZINOFILIJA – komplikacije; LEUKOCITOZA – komplikacije; IMUNOGLOBULIN M – u krvi; VRUĆICA; GLUKOKORTIKOIDI – terapijska uporaba; HIPEREOZINOFILNI SINDROM
• Keywords (english): ANGIOEDEMA – complications, diagnosis, drug therapy; EOSINOPHILIA – complications; LEUKOCYTOSIS – complications; IMMUNOGLOBULIN M – blood; FEVER; GLUCOCORTICOIDS – therapeutic use; HYPEREOSINOPHILIC SYNDROME
• Language: croatian
• Language: english
• Publication type: Scientific paper - Case study
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Liječnički vjesnik
• Numbering: vol. 144, no. 1-2, pp. 44-46
• p-ISSN: 0024-3477
• e-ISSN: 1849-2177
• DOI: https://doi.org/10.26800/LV-144-1-2-5
• URN:NBN: urn:nbn:hr:105:065256
• Publication: 2022
• Document URL: https://hrcak.srce.hr/272014
• Type of resource: Text
• Access conditions: Open access
• Created on: 2022-05-23 10:29:39