Significant Associations of IgG Glycan Structures With Chronic Graft-Versus-Host Disease Manifestations: Results of the Cross-Sectional NIH Cohort Study

Scientific paper - Original scientific paper

• Author: Ema Prenc
• Author: Dražen Pulanić
• Author: Maja Pucic-Bakovic
• Author: Ivo Ugrina
• Author: Lana Desnica
• Author: Milan Milošević
• Author: Filip Pirsl
• Author: Sandra Mitchell
• Author: Jeremy Rose
• Author: Radovan Vrhovac
• Author: Damir Nemet
• Author: Gordan Lauc
• Author: Steven Ž. Pavletić
• Author's institution: University of Zagreb; School of Medicine; (Department of Internal Medicine)
• Author's institution: University of Zagreb; School of Medicine; (Department of Environmental and Occupational Health)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Public Health and Health Care; Health Ecology

Abstract (english)

Chronic graft-versus-host disease (cGvHD) is a systemic alloimmune and autoimmune disorder and a major late complication of allogeneic hematopoietic stem cell transplantation (alloHSCT). The disease is characterized by an altered homeostasis of the humoral immune response. Immunoglobulin G (IgG) glycoprotein is the main effector molecule of the humoral immune response. Changes in IgG glycosylation are associated with a number of autoimmune diseases. IgG glycosylation analysis was done by the means of liquid chromatography in the National Institutes of Health (NIH) cohort of 213 cGvHD patients. The results showed statistically significant differences with regards to cGvHD NIH joint/fascia and skin score, disease activity and intensity of systemic immunosuppression. ROC analysis confirmed that IgG glycosylation increases specificity and sensitivity of models using laboratory parameters and markers of inflammation associated with cGvHD (eosinophil count, complement components C3 and C4 and inflammation markers: albumin, CRP and thrombocyte count). This research shows that IgG glycosylation may play a significant role in cGvHD pathology. Further research could contribute to the understanding of the disease biology and lead to the clinical biomarker development to allow personalized approaches to chronic GvHD therapy.

• Keywords (english): Adolescent; Adult; Aged; Biomarkers; Child; Child, Preschool; Chronic Disease; Cohort Studies; Complement System Proteins / metabolism; Cross-Sectional Studies; Eosinophils / pathology; Female; Glycosylation; Graft vs Host Disease / immunology; Hematopoietic Stem Cell Transplantation; Humans; Immunity, Humoral; Immunoglobulin G / chemistry; Immunoglobulin G / metabolism; Inflammation Mediators / metabolism; Male; Middle Aged; Polysaccharides / chemistry; Precision Medicine; Severity of Illness Index; Skin / pathology; Transplantation, Homologous; Young Adult
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Frontiers in Immunology
• Numbering: vol. 12, 633214
• e-ISSN: 1664-3224
• DOI: https://doi.org/10.3389/fimmu.2021.633214
• URN:NBN: urn:nbn:hr:105:644862
• Publication: 2021-07-14
• Document URL: https://www.frontiersin.org/articles/10.3389/fimmu.2021.633214/full
• Type of resource: Text
• Access conditions: Open access
• Created on: 2022-05-25 11:21:20