Awakened Beta-Cell Function Decreases the Risk of Hypoglycemia in Pregnant Women with Type 1 Diabetes Mellitus

Scientific paper - Original scientific paper

• Author: Josip Đelmiš
• Author: Marina Ivanišević
• Author's institution: University of Zagreb; School of Medicine; (Department of Gynecology and Obstetrics)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Gynecology and Obstetrics

Abstract (english)

Diabetes in pregnancy creates many problems for both the mother and child. Pregnant women with type 1 diabetes experience more frequent hypoglycemic and hyperglycemic episodes. This study aimed to determine the risk of clinically significant biochemical hypoglycemia (CSBH) by HbA1c, fasting C-peptide, mean plasma glucose (PG), and insulin dose in pregnant women type 1 diabetes mellitus according to each trimester of the pregnancy.
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Methods: We conducted a prospective observational study of 84 pregnant women with type 1 diabetes in an academic hospital. To present the hypoglycemia, we divided the participants into two groups: those who did not have clinically significant biochemical hypoglycemia (CSBH-; n = 30) and those who had clinically significant biochemical hypoglycemia (CSBH+; n = 54).
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Results: In the first, second, and third trimesters, the duration of T1DM, fasting C-peptide, and mean glucose concentration was inversely associated with CSBH.
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Conclusions: Insulin overdose is the most common risk factor for hypoglycemia. In pregnant women with type 1 diabetes with elevated fasting C-peptide levels, the insulin dose should be diminished to reduce the risk of hypoglycemia.

• Keywords (english): C-peptide; diabetes mellitus type 1; hypoglycemia; pregnancy
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Journal of Clinical Medicine
• Numbering: vol. 11, no. 4, 1050
• e-ISSN: 2077-0383
• DOI: https://doi.org/10.3390/jcm11041050
• URN:NBN: urn:nbn:hr:105:783939
• Publication: 2022-02-17
• Project: Number: IP-2018-01-1284; Title (croatian): Prevencija hipoglikemije u trudnica s dijabetesom tipa 1; Acronym: PRE-HYPO; Leader: Marina Ivanišević; Jurisdiction: Croatia; Funding stream: IP
• Document URL: https://www.mdpi.com/2077-0383/11/4/1050
• Type of resource: Text
• Access conditions: Open access
• Created on: 2022-07-11 08:21:17