prikaz prve stranice dokumenta Maternal Metabolic State and Fetal Sex and Genotype Modulate Methylation of the Serotonin Receptor Type 2A Gene (HTR2A) in the Human Placenta
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Scientific paper - Original scientific paper
Maternal Metabolic State and Fetal Sex and Genotype Modulate Methylation of the Serotonin Receptor Type 2A Gene (HTR2A) in the Human Placenta
Biomedicines, 10 (2022), 2; 467. https://doi.org/10.3390/biomedicines10020467
Horvatiček, Marina; Perić, Maja; Bečeheli, Ivona; Klasić, Marija; Žutić, Maja; Kesić, Maja; Desoye, Gernot; Nakić Radoš, Sandra; Ivanišević, Marina; Hranilović, Dubravka; Štefulj, Jasminka

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Horvatiček, M., Perić, M., Bečeheli, I., Klasić, M., Žutić, M., Kesić, M. ... Štefulj, J. (2022). Maternal Metabolic State and Fetal Sex and Genotype Modulate Methylation of the Serotonin Receptor Type 2A Gene (HTR2A) in the Human Placenta. Biomedicines, 10. (2). doi: 10.3390/biomedicines10020467

Horvatiček, Marina, et al. "Maternal Metabolic State and Fetal Sex and Genotype Modulate Methylation of the Serotonin Receptor Type 2A Gene (HTR2A) in the Human Placenta." Biomedicines, vol. 10, no. 2, 2022. https://doi.org/10.3390/biomedicines10020467

Horvatiček, Marina, Maja Perić, Ivona Bečeheli, Marija Klasić, Maja Žutić, Maja Kesić, Gernot Desoye, et al. "Maternal Metabolic State and Fetal Sex and Genotype Modulate Methylation of the Serotonin Receptor Type 2A Gene (HTR2A) in the Human Placenta." Biomedicines 10, no. 2 (2022). https://doi.org/10.3390/biomedicines10020467

Horvatiček, M., et al. (2022) 'Maternal Metabolic State and Fetal Sex and Genotype Modulate Methylation of the Serotonin Receptor Type 2A Gene (HTR2A) in the Human Placenta', Biomedicines, 10(2). doi: 10.3390/biomedicines10020467

Horvatiček M, Perić M, Bečeheli I, Klasić M, Žutić M, Kesić M, and sur.. Maternal Metabolic State and Fetal Sex and Genotype Modulate Methylation of the Serotonin Receptor Type 2A Gene (HTR2A) in the Human Placenta. Biomedicines [Internet]. 2022 February 17 [cited 2024 December 15];10(2). doi: 10.3390/biomedicines10020467

M. Horvatiček, et al., "Maternal Metabolic State and Fetal Sex and Genotype Modulate Methylation of the Serotonin Receptor Type 2A Gene (HTR2A) in the Human Placenta", Biomedicines, vol. 10, no. 2, February 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:594778. [Accessed: 15 December 2024]

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Metadata
Title (english)Maternal Metabolic State and Fetal Sex and Genotype Modulate Methylation of the Serotonin Receptor Type 2A Gene (HTR2A) in the Human Placenta
AuthorMarina Horvatiček
AuthorMaja Perić
AuthorIvona Bečeheli
AuthorMarija Klasić
AuthorMaja Žutić
AuthorMaja Kesić
AuthorGernot Desoye
AuthorSandra Nakić Radoš
AuthorMarina Ivanišević
AuthorDubravka Hranilović
AuthorJasminka Štefulj
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Gynecology and Obstetrics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Gynecology and Obstetrics
Abstract (english)
The serotonin receptor 2A gene (HTR2A) is a strong candidate for the fetal programming of future behavior and metabolism. Maternal obesity and gestational diabetes mellitus (GDM) have been associated with an increased risk of metabolic and psychological problems in offspring. We tested the hypothesis that maternal metabolic status affects methylation of HTR2A in the placenta. The prospective study included 199 pairs of mothers and healthy full-term newborns. Genomic DNA was extracted from feto-placental samples and analyzed for genotypes of two polymorphisms (rs6311, rs6306) and methylation of four cytosine residues (−1665, −1439, −1421, −1224) in the HTR2A promoter region. Placental HTR2A promoter methylation was higher in male than female placentas and depended on both rs6311 and rs6306 genotypes. A higher maternal pre-gestational body mass index (pBMI) and, to a lesser extent, diagnosis of GDM were associated with reduced HTR2A promoter methylation in female but not male placentas. Higher pBMI was associated with reduced methylation both directly and indirectly through increased GDM incidence. Tobacco use during pregnancy was associated with reduced HTR2A promoter methylation in male but not female placentas. The obtained results suggest that HTR2A is a sexually dimorphic epigenetic target of intrauterine exposures. The findings may contribute to a better understanding of the early developmental origins of neurobehavioral and metabolic disorders associated with altered HTR2A function.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBiomedicines
Numberingvol. 10, no. 2, 467
e-ISSN2227-9059
DOIhttps://doi.org/10.3390/biomedicines10020467
URN:NBNurn:nbn:hr:105:594778
Publication2022-02-17
ProjectNumber: IP-2018-01-6547
Title (croatian): Utjecaj majčinog metaboličkog stanja na serotoninski sustav posteljice i neonatusa: od metilacije DNA do funkcije proteina
Acronym: PLANS
Leader: Jasminka Štefulj
Jurisdiction: Croatia
Funding stream: IP
Document URLhttps://www.mdpi.com/2227-9059/10/2/467
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-07-18 09:20:58