prikaz prve stranice dokumenta Antinociceptive Actions of Botulinum Toxin A1 on Immunogenic Hypersensitivity in Temporomandibular Joint of Rats
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Scientific paper - Original scientific paper
Antinociceptive Actions of Botulinum Toxin A1 on Immunogenic Hypersensitivity in Temporomandibular Joint of Rats
Toxins, 14 (2022), 3; 161. https://doi.org/10.3390/toxins14030161
Muñoz-Lora, Victor Ricardo Manuel; Dugonjić Okroša, Ana; Matak, Ivica; Del Bel Cury, Altair Antoninha; Kalinichev, Mikhail; Lacković, Zdravko

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Muñoz Lora, V. R. M., Dugonjić Okroša, A., Matak, I., Del Bel Cury, A. A., Kalinichev, M. & Lacković, Z. (2022). Antinociceptive Actions of Botulinum Toxin A1 on Immunogenic Hypersensitivity in Temporomandibular Joint of Rats. Toxins, 14. (3). doi: 10.3390/toxins14030161

Muñoz Lora, Victor Ricardo Manuel, et al. "Antinociceptive Actions of Botulinum Toxin A1 on Immunogenic Hypersensitivity in Temporomandibular Joint of Rats." Toxins, vol. 14, no. 3, 2022. https://doi.org/10.3390/toxins14030161

Muñoz Lora, Victor Ricardo Manuel, Ana Dugonjić Okroša, Ivica Matak, Altair Antoninha Del Bel Cury, Mikhail Kalinichev and Zdravko Lacković. "Antinociceptive Actions of Botulinum Toxin A1 on Immunogenic Hypersensitivity in Temporomandibular Joint of Rats." Toxins 14, no. 3 (2022). https://doi.org/10.3390/toxins14030161

Muñoz Lora, V. R. M., et al. (2022) 'Antinociceptive Actions of Botulinum Toxin A1 on Immunogenic Hypersensitivity in Temporomandibular Joint of Rats', Toxins, 14(3). doi: 10.3390/toxins14030161

Muñoz Lora VRM, Dugonjić Okroša A, Matak I, Del Bel Cury AA, Kalinichev M, Lacković Z. Antinociceptive Actions of Botulinum Toxin A1 on Immunogenic Hypersensitivity in Temporomandibular Joint of Rats. Toxins [Internet]. 2022 February 23 [cited 2024 December 28];14(3). doi: 10.3390/toxins14030161

V. R. M. Muñoz Lora, A. Dugonjić Okroša, I. Matak, A. A. Del Bel Cury, M. Kalinichev and Z. Lacković, "Antinociceptive Actions of Botulinum Toxin A1 on Immunogenic Hypersensitivity in Temporomandibular Joint of Rats", Toxins, vol. 14, no. 3, February 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:714770. [Accessed: 28 December 2024]

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Metadata
Title (english)Antinociceptive Actions of Botulinum Toxin A1 on Immunogenic Hypersensitivity in Temporomandibular Joint of Rats
AuthorVictor Ricardo Manuel Muñoz-Lora
AuthorAna Dugonjić Okroša
AuthorIvica Matak
AuthorAltair Antoninha Del Bel Cury
AuthorMikhail Kalinichev
AuthorZdravko Lacković
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pharmacology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Pharmacology
Abstract (english)
Botulinum neurotoxin type A1 (BoNT-A) reduces the peripheral peptide and cytokine upregulation in rats with antigen-evoked persistent immunogenic hypersensitivity (PIH) of the temporomandibular joint (TMJ). Herein, we examined the effects of two preparations of BoNT-A, abobotulinumtoxinA (aboBoNT-A; Dysport) and onabotulinumtoxinA (onaBoNT-A; Botox), on spontaneous and evoked nociceptive behaviors, as well as on central neuronal and astroglial activation. The antigen-evoked PIH was induced in rats via repeated systemic and unilateral intra-articular (i.a.) injections of methylated bovine serum albumin (mBSA). Rats were subsequently injected with unilateral i.a. aboBoNT-A (14 U/kg), onaBoNT-A (7 U/kg), or the vehicle (saline). After i.a. treatments, spontaneous and mechanically evoked nocifensive behaviors were assessed before and after the low-dose i.a. formalin (0.5%) challenge. The central effects of BoNT-A were assessed by an immunohistochemical analysis of cleaved synaptosomal-associated protein 25 (cSNAP-25) presence, c-Fos, GFAP, and CGRP expression in the trigeminal nucleus caudalis (TNC). Both BoNT-A preparations similarly reduced the formalin-induced spontaneous pain-related behaviors and mechanical allodynia of the hypernociceptive rats. Likewise, their effects were associated with the central occurrence of cSNAP-25 and reduction of c-Fos and GFAP upregulation in the TNC. BoNT-A antinociceptive activity on the PIH is associated with the toxin axonal transport to trigeminal sensory areas and reduction of neuronal and glial activation in central nociceptive regions.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleToxins
Numberingvol. 14, no. 3, 161
e-ISSN2072-6651
DOIhttps://doi.org/10.3390/toxins14030161
URN:NBNurn:nbn:hr:105:714770
Publication2022-02-23
Document URLhttps://www.mdpi.com/2072-6651/14/3/161
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-09-28 09:42:12