prikaz prve stranice dokumenta Post-mortem Findings of Inflammatory Cells and the Association of 4-Hydroxynonenal with Systemic Vascular and Oxidative Stress in Lethal COVID-19
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Scientific paper - Original scientific paper
Post-mortem Findings of Inflammatory Cells and the Association of 4-Hydroxynonenal with Systemic Vascular and Oxidative Stress in Lethal COVID-19
Cells, 11 (2022), 3; 444. https://doi.org/10.3390/cells11030444
Žarković, Neven; Jakovčević, Antonia; Mataić, Ana; Jaganjac, Morana; Vuković, Tea; Waeg, Georg; Žarković, Kamelija

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Žarković, N., Jakovčević, A., Mataić, A., Jaganjac, M., Vuković, T., Waeg, G. & Žarković, K. (2022). Post-mortem Findings of Inflammatory Cells and the Association of 4-Hydroxynonenal with Systemic Vascular and Oxidative Stress in Lethal COVID-19. Cells, 11. (3). doi: 10.3390/cells11030444

Žarković, Neven, et al. "Post-mortem Findings of Inflammatory Cells and the Association of 4-Hydroxynonenal with Systemic Vascular and Oxidative Stress in Lethal COVID-19." Cells, vol. 11, no. 3, 2022. https://doi.org/10.3390/cells11030444

Žarković, Neven, Antonia Jakovčević, Ana Mataić, Morana Jaganjac, Tea Vuković, Georg Waeg and Kamelija Žarković. "Post-mortem Findings of Inflammatory Cells and the Association of 4-Hydroxynonenal with Systemic Vascular and Oxidative Stress in Lethal COVID-19." Cells 11, no. 3 (2022). https://doi.org/10.3390/cells11030444

Žarković, N., et al. (2022) 'Post-mortem Findings of Inflammatory Cells and the Association of 4-Hydroxynonenal with Systemic Vascular and Oxidative Stress in Lethal COVID-19', Cells, 11(3). doi: 10.3390/cells11030444

Žarković N, Jakovčević A, Mataić A, Jaganjac M, Vuković T, Waeg G, and sur.. Post-mortem Findings of Inflammatory Cells and the Association of 4-Hydroxynonenal with Systemic Vascular and Oxidative Stress in Lethal COVID-19. Cells [Internet]. 2022 January 27 [cited 2024 April 19];11(3). doi: 10.3390/cells11030444

N. Žarković, et al., "Post-mortem Findings of Inflammatory Cells and the Association of 4-Hydroxynonenal with Systemic Vascular and Oxidative Stress in Lethal COVID-19", Cells, vol. 11, no. 3, January 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:043899. [Accessed: 19 April 2024]

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Metadata
Title (english)Post-mortem Findings of Inflammatory Cells and the Association of 4-Hydroxynonenal with Systemic Vascular and Oxidative Stress in Lethal COVID-19
AuthorNeven Žarković
AuthorAntonia Jakovčević
AuthorAna Mataić
AuthorMorana Jaganjac
AuthorTea Vuković
AuthorGeorg Waeg
AuthorKamelija Žarković
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Pathology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Abstract (english)
A recent comparison of clinical and inflammatory parameters, together with biomarkers of oxidative stress, in patients who died from aggressive COVID-19 and survivors suggested that the lipid peroxidation product 4-hydroxynonenal (4-HNE) might be detrimental in lethal SARS-CoV-2 infection. The current study further explores the involvement of inflammatory cells, systemic vascular stress, and 4-HNE in lethal COVID-19 using specific immunohistochemical analyses of the inflammatory cells within the vital organs obtained by autopsy of nine patients who died from aggressive SAR-CoV-2 infection. Besides 4-HNE, myeloperoxidase (MPO) and mitochondrial superoxide dismutase (SOD2) were analyzed alongside standard leukocyte biomarkers (CDs). All the immunohistochemical slides were simultaneously prepared for each analyzed biomarker. The results revealed abundant 4-HNE in the vital organs, but the primary origin of 4-HNE was sepsis-like vascular stress, not an oxidative burst of the inflammatory cells. In particular, inflammatory cells were often negative for 4-HNE, while blood vessels were always very strongly immunopositive, as was edematous tissue even in the absence of inflammatory cells. The most affected organs were the lungs with diffuse alveolar damage and the brain with edema and reactive astrocytes, whereas despite acute tubular necrosis, 4-HNE was not abundant in the kidneys, which had prominent SOD2. Although SOD2 in most cases gave strong immunohistochemical positivity similar to 4-HNE, unlike 4-HNE, it was always limited to the cells, as was MPO. Due to their differential expressions in blood vessels, inflammatory cells, and the kidneys, we think that SOD2 could, together with 4-HNE, be a potential link between a malfunctioning immune system, oxidative stress, and vascular stress in lethal COVID-19.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCells
Numberingvol. 11, no. 3, 444
e-ISSN2073-4409
DOIhttps://doi.org/10.3390/cells11030444
URN:NBNurn:nbn:hr:105:043899
Publication2022-01-27
Document URLhttps://www.mdpi.com/2073-4409/11/3/444
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-10-20 09:20:48