Utjecaj unosa joda na funkcionalne parametre štitnjače u trudnica

doctoral thesis

• Title (english): The impact of iodine intake on functional parameters of the thyroid in pregnant women
• Author: Vedrana Gladić Nenadić
• Mentor: Tomislav Jukić (mentor)
• Committee member: Dražen Huić (predsjednik povjerenstva)
• Committee member: Tina Dušek (član povjerenstva)
• Committee member: Krunoslav Kuna (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2022-09-02, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Nuclear Medicine
• Universal decimal classification (UDC): 616 - Pathology. Clinical medicine

Abstract

Istraživanje je proučavalo utjecaj unosa joda na funkciju i volumen štitnjače (Tvol) u trudnica na području Zagreba. Unos joda je određen mjerenjem koncentracije joda u urinu (UIC). Cilj istraživanja bio je utvrditi unos joda i utjecaj dodatnog unosa joda putem dodataka prehrani u trudnica u svim trimestrima trudnoće na funkciju i Tvol, vrijednost tireoglobulina (Tg) kao biljega unosa joda u trudnoći i utjecaj morfoloških promjena štitnjače na njegovu vrijednost. Hipoteza istraživanja je da trudnice koje ne uzimaju dodatke prehrani s jodom imaju niže vrijednosti UIC, niže koncentracije slobodnog tiroksina (FT4), više koncentracije tireotropina (TSH) i Tg-a u serumu i veći Tvol. Istraživanje je obuhvatilo 91 trudnicu koje su uzimale i 100 trudnica koje nisu uzimale dodatke prehrani s jodom. Medijan UIC u trudnica koje nisu uzimale dodatke prehrani s jodom iznosio je 158 μg/L, a koje su uzimale 169 μg/L, što je dostatan unos joda u obje skupine i cjelokupnom uzorku. Trudnice koje nisu uzimale dodatke prehrani s jodom imale su statistički značajno niže vrijednosti FT4, a više vrijednosti Tg-a i Tvol (p˂0.05). Tireoglobulin je koristan biljeg unosa joda u trudnoći. Difuzne promjene štitnjače značajno povećavaju razinu Tg-a u serumu. Nije utvrđena korelacija Tg-a i ostalih ispitivanih prametara štitnjače.

Abstract (english)

The study investigated the impact of iodine intake on thyroid function (TF) and thyroid volume (Tvol) in pregnant women from Zagreb. Iodine status was determined by measurement of urinary iodine concentration (UIC). The aim of the study was to asess iodine intake and the impact of iodine supplementation (IS) in pregnant women in all trimesters of pregnancy on TF and Tvol, the value of Thyroglobulin (Tg) as potential biomarker of iodine intake in pregnancy as well as the influence of morphological changes on Tg measurement. It is hypothesized that pregnant women without IS have lower UIC values, lower free thyroxine (FT4), higher thyrotropin (TSH) and higher serum Tg concentrations, as well as higher Tvol. We enrolled 91 pregnant women with IS and 100 pregnant women without IS. Median UIC was 158 μg/L in pregnant women without IS, and 169 μg/L in pregnant women with IS, indicating sufficient iodine intake in both groups as well as in overall sample. Pregnant women without IS had significantly lower FT4, and higher Tg and Tvol values (p˂0.05). Thyroglobulin is a valuable biomarker of iodine intake in pregnancy. Diffuse thyroid pattern increases Tg values. There was no correlation between Tg and other thyroid parameters.

• Keywords: Trudnoća; Tiroksin; Tireoglobulin; Štitnjača; Trudnice; Jod; Thyrotropin; Dodaci prehrani; Biomarkeri
• Keywords (english): Pregnancy; Thyroxine; Thyroglobulin; Thyroid Gland; Pregnant Women; Iodine; Thyrotropin; Dietary Supplements; Biomarkers
• Language: croatian
• URN:NBN: urn:nbn:hr:105:003942
• Study programme: Title: Biomedicine and Health Sciences; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
• Type of resource: Text
• Extent: 100 str.
• File origin: Born digital
• Access conditions: Open access; Embargo expiration date: 2024-09-02
• Created on: 2022-10-28 11:18:11