prikaz prve stranice dokumenta Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate
  Download
PDF 20.53 MB
Scientific paper - Original scientific paper
Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate
Nature Communications, 13 (2022), 1; 633. https://doi.org/10.1038/s41467-021-27602-z
Parichha, Arpan; Suresh, Varun; Chatterjee, Mallika; Kshirsagar, Aditya; Ben-Reuven, Lihi; Olender, Tsviya; Taketo, M. Mark; Radošević, Velena; Bobić-Rasonja, Mihaela; Trnski, Sara; Holtzman, Michael J.; Jovanov-Milošević, Nataša; Reiner, Orly; Tole, Shubha

Cite this document

Parichha, A., Suresh, V., Chatterjee, M., Kshirsagar, A., Ben Reuven, L., Olender, T. ... Tole, S. (2022). Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate. Nature Communications, 13. (1). doi: 10.1038/s41467-021-27602-z

Parichha, Arpan, et al. "Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate." Nature Communications, vol. 13, no. 1, 2022. https://doi.org/10.1038/s41467-021-27602-z

Parichha, Arpan, Varun Suresh, Mallika Chatterjee, Aditya Kshirsagar, Lihi Ben Reuven, Tsviya Olender, M. Mark Taketo, et al. "Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate." Nature Communications 13, no. 1 (2022). https://doi.org/10.1038/s41467-021-27602-z

Parichha, A., et al. (2022) 'Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate', Nature Communications, 13(1). doi: 10.1038/s41467-021-27602-z

Parichha A, Suresh V, Chatterjee M, Kshirsagar A, Ben Reuven L, Olender T, and sur.. Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate. Nature Communications [Internet]. 2022 February [cited 2024 May 03];13(1). doi: 10.1038/s41467-021-27602-z

A. Parichha, et al., "Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate", Nature Communications, vol. 13, no. 1, February 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:947172. [Accessed: 03 May 2024]

Please login to the repository to save this object to your list.
Metadata
Title (english)Constitutive activation of canonical Wnt signaling disrupts choroid plexus epithelial fate
AuthorArpan Parichha
AuthorVarun Suresh
AuthorMallika Chatterjee
AuthorAditya Kshirsagar
AuthorLihi Ben-Reuven
AuthorTsviya Olender
AuthorM. Mark Taketo
AuthorVelena Radošević
AuthorMihaela Bobić-Rasonja
AuthorSara Trnski
AuthorMichael J. Holtzman
AuthorNataša Jovanov-Milošević
AuthorOrly Reiner
AuthorShubha Tole
Author's institutionUniversity of Zagreb
School of Medicine
(Croatian Institiute for Brain Research)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Medical Biology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Neuroscience
Abstract (english)
The choroid plexus secretes cerebrospinal fluid and is critical for the development and function of the brain. In the telencephalon, the choroid plexus epithelium arises from the Wnt- expressing cortical hem. Canonical Wnt signaling pathway molecules such as nuclear β-CATENIN are expressed in the mouse and human embryonic choroid plexus epithelium indicating that this pathway is active. Point mutations in human β-CATENIN are known to result in the constitutive activation of canonical Wnt signaling. In a mouse model that recapitulates this perturbation, we report a loss of choroid plexus epithelial identity and an apparent transformation of this tissue to a neuronal identity. Aspects of this phenomenon are recapitulated in human embryonic stem cell derived organoids. The choroid plexus is also disrupted when β-Catenin is conditionally inactivated. Together, our results indicate that canonical Wnt signaling is required in a precise and regulated manner for normal choroid plexus development in the mammalian brain.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleNature Communications
Numberingvol. 13, no. 1, 633
e-ISSN2041-1723
DOIhttps://doi.org/10.1038/s41467-021-27602-z
URN:NBNurn:nbn:hr:105:947172
Publication2022-02
Document URLhttps://www.nature.com/articles/s41467-021-27602-z
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-11-14 10:21:51