Utjecaj širine vjeđnoga rasporka na disfunkciju suznoga filma

doctoral thesis

• Title (english): The influence of palpebral fissure width on the tear film dysfunction
• Author: Ana Čović
• Mentor: Igor Petriček (mentor)
• Committee member: Miro Kalauz (predsjednik povjerenstva)
• Committee member: Tomislav Kuzman (član povjerenstva)
• Committee member: Ivanka Petric Vicković (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2022-10-17, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Ophthalmology
• Universal decimal classification (UDC): 617 - Surgery. Orthopaedics. Ophthalmology

Abstract

Cilj: Ispitati utjecaj širine vjeđnog rasporka mjerenog plastičnim ravnalom u primarnom
položaju oka pri pogledu ravno naprijed na disfunkciju suznog filma kod zdravih
pojedinaca, i to u odnosu na dob i spol. ----- Metode: U ovo presječno istraživanje je bilo
uključeno 120 ispitanika podijeljenih u dvije skupine prema životnoj dobi s podjednakim
omjerom žena i muškaraca u skupinama. Dob od 50 godina određena je kao granična.
Obje skupine uključivale su 30 ispitanika s prisutnim simptomima disfunkcije suznog
filma. Za procjenu simptoma disfunkcije suznog filma koristio se Scheinov upitnik, a za
procjenu kliničkih znakova hiperemija spojnice, NIBUT, ekspresija Meibomovih žlijezdi,
TBUT, bojenje rožnice fluoresceinom te LIPCOF. ----- Rezultati: Simptomi disfunkcije
suznog filma bili su značajno izraženiji i učestaliji kod žena mlađe životne dobi i većih
prosječnih vrijednosti širine vjeđnog rasporka. U žena starije životne dobi utvrđena je
značajno negativna povezanost širine vjeđnog rasporka i učestalosti simptoma. Širina
vjeđnog rasporka bila je značajno negativno povezana s vrijednostima NIBUT-a i
TBUT-a u ispitanika mlađe i starije životne dobi te značajno pozitivno s pozitivnim
nalazom bojenja rožnice fluoresceinom i većim vrijednostima LIPCOF-a u skupini
ispitanika sa simptomima neovisno o dobi. Povezanost iste je sa hiperemijom spojnice
i zamućenim izgledom sekreta Meibomovih žlijezdi bila značajno negativna u skupini
sa prisutnim simptomima disfunkcije suznog filma. Izraženija hiperemija spojnice, viši
LIPCOF i kraći TBUT u ovom su istraživanju bili najbolji prediktori i indikatori za
prisutnost i razvoj disfunkcije suznog filma. ----- Zaključak: Širina vjeđnog rasporka je kao
osobni čimbenik, mogući indikator i prediktor razvoja pretežito evaporativne
komponentne disfunkcije suznog filma kod zdravih pojedinaca te u kombinaciji s
procjenom simptoma i kliničkih znakova, koristan alat u dijagnostičkom algoritmu
disfunkcije suznog filma u svakodnevnoj kliničkoj praksi, i to u sklopu standardnog
oftalmološkog pregleda.

Abstract (english)

Aim: To determine the influence of palpebral fissure width measured with plastic ruler
in a primary gaze position on the tear film dysfunction in healthy individuals, according
to age and gender. ----- Methods: 120 subjects were enrolled in this cross-sectional study
and divided according to age into two groups with an equal distribution of men and
women. Age of 50 was determined as an age limit. Both of the groups included 30
subjects with and without tear film dysfunction symptoms. Schein questionnaire was
used in order to determine the presence of the tear film dysfunction symptoms. Ocular
signs were assessed by conjunctival hyperemia, NIBUT, Meibomiam gland
expressibility, TBUT, corneal staining and LIPCOF. ----- Results: Symptoms of the tear film
dysfunction were significantly more pronounced and more frequent in younger women
with higher mean values of the palpebral fissure width. In older women, a significantly
negative correlation was found between the palpebral fissure width and the frequency
of symptoms. Palpebral fissure width was significantly negatively associated with
NIBUT and TBUT values in younger and older subjects and significantly positively with
a positive finding of corneal fluorescein staining and higher LIPCOF values in the group
of subjects with symptoms regardless of age. Correlation of the same with conjunctival
hyperemia and cloudy appearance of Meibomian gland secretions was significantly
negative in the group with symptoms of the tear film dysfunction. Conjunctival
hyperemia, LIPCOF and TBUT were the best indicators and predictors of the tear film
dysfunction. ----- Conclusion: As a personal factor, palpebral fissure width is a possible
indicator and predictor of the predominantly evaporative tear film dysfunction in healthy
individuals and in the combination with the assessment of symptoms and clinical signs,
an useful tool in diagnostic algorithm for the tear film dysfunction in everyday clinical
practice, as a part of the standard ophthalmological examination.

• Keywords: Meibomove žlijezde; Hiperemija; Suzni film
• Keywords (english): Meibomian glands; Hyperemia; Tear film
• Language: croatian
• URN:NBN: urn:nbn:hr:105:776524
• Study programme: Title: Biomedicine and Health Sciences; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor/doktorica znanosti, područje biomedicine i zdravstvo (doktor/doktorica znanosti, područje biomedicine i zdravstvo)
• Type of resource: Text
• Extent: 180 str.
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-11-22 10:09:52