prikaz prve stranice dokumenta Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder
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Scientific paper - Original scientific paper
Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder
Scientific Reports, 12 (2022), 1; 7973. https://doi.org/10.1038/s41598-022-11516-x
Gelegen, Cigdem; Cash, Diana; Ilić, Katarina; Sander, Millie; Kim, Eugene; Simmons, Camilla; Bernanos, Michel; Lama, Joana; Randall, Karen; Brown, Jonathan T.; Kalanj-Bognar, Svjetlana; Cooke, Samuel; Ray Chaudhuri, K.; Ballard, Clive; Francis, Paul; Rosenzweig, Ivana More authors...

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Gelegen, C., Cash, D., Ilić, K., Sander, M., Kim, E., Simmons, C. ... Rosenzweig, I. (2022). Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder. Scientific Reports, 12. (1). doi: 10.1038/s41598-022-11516-x

Gelegen, Cigdem, et al. "Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder." Scientific Reports, vol. 12, no. 1, 2022. https://doi.org/10.1038/s41598-022-11516-x

Gelegen, Cigdem, Diana Cash, Katarina Ilić, Millie Sander, Eugene Kim, Camilla Simmons, Michel Bernanos, et al. "Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder." Scientific Reports 12, no. 1 (2022). https://doi.org/10.1038/s41598-022-11516-x

Gelegen, C., et al. (2022) 'Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder', Scientific Reports, 12(1). doi: 10.1038/s41598-022-11516-x

Gelegen C, Cash D, Ilić K, Sander M, Kim E, Simmons C, and sur.. Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder. Scientific Reports [Internet]. 2022 May 13 [cited 2024 April 12];12(1). doi: 10.1038/s41598-022-11516-x

C. Gelegen, et al., "Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder", Scientific Reports, vol. 12, no. 1, May 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:483020. [Accessed: 12 April 2024]

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Metadata
Title (english)Relevance of sleep and associated structural changes in GBA1 mouse to human rapid eye movement behavior disorder
AuthorCigdem Gelegen
AuthorDiana Cash
AuthorKatarina Ilić
AuthorMillie Sander
AuthorEugene Kim
AuthorCamilla Simmons
AuthorMichel Bernanos
AuthorJoana Lama
AuthorKaren Randall
AuthorJonathan T. Brown
AuthorSvjetlana Kalanj-Bognar
AuthorSamuel Cooke
AuthorK. Ray Chaudhuri
AuthorClive Ballard
AuthorPaul Francis
AuthorIvana Rosenzweig
Author's institutionUniversity of Zagreb
School of Medicine
(Croatian Institiute for Brain Research)
Author's institutionUniversity of Zagreb
School of Medicine
(Department of Medical Chemistry, Biochemistry and Clinical Chemistry)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Neuroscience
Abstract (english)
Rapid eye movement (REM) sleep behaviour disorder (RBD) is a REM parasomnia that often predicts the later ct occurrence of alpha-synucleinopathies. Variants in the gene encoding for the lysosomal enzyme glucocerebrosidase, GBA, strongly increase the risk of RBD. In a GBA1-mouse model recently shown to mimic prodromal stages of α-synucleinopathy, we now demonstrate striking REM and NREM electroencephalographic sleep abnormalities accompanied by distinct structural changes in the more widespread sleep neurocircuitry.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleScientific Reports
Numberingvol. 12, no. 1, 7973
e-ISSN2045-2322
DOIhttps://doi.org/10.1038/s41598-022-11516-x
URN:NBNurn:nbn:hr:105:483020
Publication2022-05-13
Document URLhttps://www.nature.com/articles/s41598-022-11516-x
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 4.0 International (CC BY 4.0) icon
Created on2022-12-14 08:56:07