Perinatal infections and perinatal outcomes

master's thesis

• Title (croatian): Perinatalne infekcije i perinatalni ishod
• Author: Noy Aviv
• Mentor: Josip Juras (mentor)
• Committee member: Josip Juras (predsjednik povjerenstva)
• Committee member: Vito Starčević (član povjerenstva)
• Committee member: Dinka Pavičić Baldani (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2021-11, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Pediatrics

Abstract

Preterm premature rupture of the membranes (PPROM) is a condition that can lead to maternal, fetal, and neonatal morbidity and mortality. It happens in 3% of pregnancies and is the cause of one-third of the total number of preterm births. An infection has been implicated both as a common underlying cause and a consequence of PPROM.
The challenge in managing PPROM is the need to balance the risk of prematurity with the risk of fetal infection and other complications. The management differs according to the gestational age at PPROM (before limit of viability, 23+0 to 33+6, 34+0 to 36+6) and generally includes either delivery induction or expectant management. Expectant management consists of monitoring, administering corticosteroids, tocolytics, magnesium sulfate, prophylactic antibiotic therapy, and screening for infections.
The period between rupture of membranes (ROM) and delivery is called latency period and it can take hours, days, and even weeks. The main question of this review is the influence of its length on the perinatal outcomes. It seems that long latency generally has a beneficial effect on the primary outcomes. However, a higher rate of chorioamnionitis and funisitis has increased with long latency, and it has a potential for long-term neurological complications.

Abstract (croatian)

Prijevremeno prsnuće vodenjaka prije termina (PPROM) stanje je koje može dovesti do pobolijevanja i smrti majke majke, fetusa ili novorođenčeta. Javlja se u 3% trudnoća i uzrok je jedne trećine ukupnog broja prijevremenih porođaja. Infekciju se može pronaći i kao uzrok i kao posljedicu PPROM-a.
Izazov u terapijsko pristupu trudnoći s PPROM-om je potreba da se uravnoteži rizik od nedonošenosti s rizikom od infekcije fetusa i drugih komplikacija. Liječenje se razlikuje ovisno o gestacijskoj dobi kada se dogodi PPROM (prije granice vijabilnosti, 23+0 do 33+6 tjedana gestacije ili 34+0 do 36+6) i općenito uključuje ili indukciju porođaja ili liječenje uz daljnji nastavak trudnoće. Uobičajeno liječenje sastoji se od praćenja, primjene kortikosteroida, tokolitika, magnezijevog sulfata, profilaktičke antibiotske terapije i probira na infekcije.
Razdoblje između rupture membrane i porođaja naziva se razdobljem latencije i može potrajati satima, danima, pa čak i tjednima. Glavno pitanje ovog pregleda je utjecaj njegove duljine na perinatalne ishode. Čini se da duga latencija općenito ima povoljan učinak na primarne ishode. Međutim, viša stopa korioamnionitisa i funisitisa porasla je s dugom latencijom i nosi rizik od nastanka dugoročnih neuroloških komplikacija.

• Keywords: PPROM; length of latency; chorioamnionitis; neurological outcomes
• Keywords (english): PPROM; duljina latencije; korioamnionitis; neurološki ishodi
• Language: croatian
• URN:NBN: urn:nbn:hr:105:855303
• Study programme: Title: Medicine (in English language); Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-12-15 12:39:48