Oocyte cryopreservation for non-medical reasons

master's thesis

• Title (croatian): Krioprezervacija jajnih stanica zbog nemedicinskih razloga
• Author: Qi Zhu
• Mentor: Maja Banović (mentor)
• Committee member: Maja Banović (predsjednik povjerenstva)
• Committee member: Mato Pavić (član povjerenstva)
• Committee member: Dinka Pavičić Baldani (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; Zagreb
• Defense date and country: 2021-11-22, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Gynecology and Obstetrics

Abstract

"Oocyte cryopreservation for non-medical reasons," also referred to as
"oocyte banking for anticipated gamete exhaustion" by Stoop et al. is when
oocyte cryopreservation is used for non-medical purposes. It is a reliable
and effective technique for women who desire to preserve fertility. Studies
have pointed out that there is a high “no use” rate which is when patients
don’t come back for oocytes since they have found a partner in the
meantime and got pregnant spontaneously. The two procedures - slow
freezing of oocytes and vitrification are described in the article together
with a short summary of the evolution of oocyte cryopreservation. Through
the evaluation of numerous studies and reviews, it is safe to conclude that
the awareness of social oocyte freezing is rising in the general population.
The success rate of oocyte cryopreservation is dependent on many factors
such as the age of the woman at the time of freezing/thawing, the number
of oocytes frozen, the level of anti-müllerian hormone at the time of
freezing, etc. Although the process of social oocyte freezing brings
advantages to many women, it is important to inform them about risks such
as ovarian hyperstimulation syndrome, the possibility of treatment success
as well as risks that are brought by late maternity. It is still too early to
make any definite conclusions on the outcome of social oocyte freezing,
and even though there are significant advancements in the
cryopreservation of mammalian oocytes, a lot regarding the molecular and
biochemical mechanisms is still to be discovered.

Abstract (croatian)

Krioprezervacija jajnih stanica zbog nemedicinskih razloga omgućava
očuvanje plodnosti za žene koje zbog socijalno-ekonomskih razloga žele
odgoditi trudnoću. Istraživanja su pokazala da postoji visoki postotak oocita
koji se nikad ne upotrijebe, što dovodi do niske isplativosti postupka.
Pacijentice se ne vraćaju po oocite jer su u međuvremenu pronašle
partnera i spontano zatrudnjele. Dva postupka, polagano zamrzavanje
oocita i vitrifikacija, opisana su u ovoj radnji zajedno s kratkim sažetkom
razvoja krioprezervacije jajnih stanica. Temeljem brojnih provedenih studija
u općoj populaciji, može se sa sigurnošću zaključiti da svijest o društvenom
zamrzavanju oocita raste. Uspješnost krioprezervacije jajnih stanica ovisi o
mnogim čimbenicima kao što su dob žene u vrijeme zamrzavanja, broj
zamrznutih oocita, razina Anti-Müllerovog hormona u vrijeme zamrzavanja,
itd. Iako ovaj postupak nudi različite mogućnosti, pacijentice je važno
informirati o rizicima poput sindroma hiperstimulacije jajnika, stopi
uspješnosti liječenja, kao i rizicima koje donosi trudnoća u odmakloj dobi.
Iako je recentni napredak u krioprezervaciji oocita sisavaca impresivan, još
se mnogo toga tek treba otkriti o molekularnim i biokemijskim
mehanizmima, a samim time je i prerano donositi bilo kakve definitivne
zaključke o ishodu zamrzavanja jajnih stanica iz socio-ekonomskih
razloga.

• Keywords: Pregnancy; Vitrification; Ovarian Hyperstimulation Syndrome; Cryopreservation; Germ Cells
• Keywords (croatian): Trudnoća; Vitrifikacija; Sindrom hiperstimulacije jajnika; Krioprezervacija; Zametne stanice
• Language: english
• URN:NBN: urn:nbn:hr:105:175337
• Study programme: Title: Medicine (in English language); Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-12-29 10:18:02