Kardiovaskularni rizik u žena

master's thesis

• Title (english): Cardiovascular risk in women
• Author: Anja Bimbašić
• Mentor: Sandra Jakšić Jurinjak (mentor)
• Committee member: Jadranka Šeparović Hanževački (predsjednik povjerenstva)
• Committee member: Martina Lovrić Benčić (član povjerenstva)
• Committee member: Sandra Jakšić Jurinjak (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2022-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract

Uvod: Kardiovaskularne bolesti vodeći su uzrok smrti žena u Europi i svijetu. Žene imaju lošije ishode bolesti i viši mortalitet. Često isti rizični čimbenik kod žena donosi viši rizik od kardiovaskularnih incidenata, u usporedbi s istim rizičnim faktorima kod muškaraca. Specifičnosti kardiovaskularnih bolesti u žena su nedovoljno proučene, nedovoljno prepoznate, nedovoljno dijagnosticirane i posljedično tome nedovoljno liječene. -----
Cilj: Cilj rada je istražiti učestalost triju kardiovaskularnih čimbenika rizika (arterijska hipertenzija, dislipidemija i dijabetes melitus tip 2) te izračunati Charlston Comorbidity Index u ispitanica s hemodinamski značajnom bolesti više srčanih zalistaka.
Metode: U retrospektivno istraživanje uključene su 34 ispitanice u dobi od 48 do 87 godina (prosjek 70.3, medijan 72.5) s hemodinamski značajnom degenerativnom bolesti više srčanih zalistaka, koje su se liječile u Klinici za bolesti srca i krvnih žila KBC Zagreb. Podaci su dobiveni retrogradnom analizom podataka iz bolničkog informacijskog sustava od 2017. do 2021. godine. -----
Rezultati: Arterijsku hipertenziju u anamnezi imale su sve 34 ispitanice (100%). Dislipidemija utvrđena je kod 22 ispitanice (64.7%), a dijabetes melitus kod 7 ispitanica (20.6%). Prosječna životna dob ispitanica je 70.3 godine. Izračunat je pojedinačni Charlson Comorbidity Index (raspon 1-8, prosjek 4.24, medijan 4) te je predviđeno prosječno desetogodišnje preživljenje 53%. -----
Zaključak: Učestalost ovih kardiovaskularnih čimbenika rizika u ispitanica s degenerativnim bolestima zalistaka je bila konzistentno viša u usporedbi sa ženama u općoj populaciji. Potrebno je pobliže istražiti čimbenike rizika i specifičnu etiopatogenezu kardiovaskularnih bolesti u žena kako bi se poboljšao ishod tih bolesti u žena.

Abstract (english)

Introduction: Cardiovascular diseases are the leading cause of death in women in Europe and the world. Women have worse outcomes and higher mortality. A risk factor in women can often have a higher risk of cardiovascular incidents, when compared to men with the same risk factor. Cardiovascular diseases in women are understudied, under-recognized, underdiagnosed and consequently, undertreated. -----
Objectives: The objective of this paper is to explore the frequency of three cardiovascular risk factors (arterial hypertension, dyslipidemia and diabetes mellitus type 2) and to calculate the Charlson Comorbidity Index of female subjects with hemodynamically significant multiple valvular heart disease. -----
Methods: 34 female subjects with hemodynamically significant multiple valvular heart disease who were treated at the Department of Cardiovascular diseases in the UHC Zagreb, aged 48 to 87 (average 70.3, median 72.5), were included in the retrospective study. The data was gathered through retrograde analysis of the data in the hospital information system from 2017 until 2021. -----
Results: All 34 subjects (100%) had arterial hypertension in their past medical history. Dyslipidemia was found in 22 subjects (64.7%) and diabetes mellitus in 7 subjects (20.6%). The Charlson Comorbidity Index was calculated individually (span 1-8, average 4.24, median 4) and the average estimated 10-year survival is 53%. -----
Conclusion: The frequency of these cardiovascular risk factors in the subjects was consistently higher when compared to women in the general population. It is necessary to investigate the risk factors and the specific etiopathogenesis of cardiovasular diseases in women more thoroughly, to improve the outcome of these diseases in women.

• Keywords: Charlson Comorbidity Index; kardiovaskularne bolesti u žena; kardiovaskularni rizik u žena
• Keywords (english): Charlson Comorbidity Index; cardiovascular diseases in women; cardiovascular risk in women
• Language: croatian
• URN:NBN: urn:nbn:hr:105:637216
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-01-03 12:02:48