Učinak terapije ibrutinibom u bolesnika s kroničnom limfocitnom leukemijom

master's thesis

• Title (english): Effect of ibrutinib therapy in patients with chronic lymphocytic leukemia
• Author: Katarina Božić
• Mentor: Slobodanka Ostojić-Kolonić (mentor)
• Committee member: Delfa Radić Krišto (predsjednik povjerenstva)
• Committee member: Jasenka Markeljević (član povjerenstva)
• Committee member: Slobodanka Ostojić-Kolonić (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Internal Medicine); Zagreb
• Defense date and country: 2022-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Internal Medicine

Abstract

Kronična limfocitna leukemija (KLL) najčešća je leukemija razvijenog svijeta. Bolest je odrasle dobi, koja se češće javlja kod muškaraca. Otkriće novih lijekova koji ciljano djeluju na tumorske stanice uvelike je promijenilo pristup u liječenju bolesnika oboljelih od tumora, a tako i onih s kroničnom limfocitnom leukemijom. Jedan od tih lijekova je i ibrutinib (Imbruvica), prvi otkriven ireverzibilni blokator Brutonove tirozin kinaze (BTK). BTK je molekula koja ima ključnu ulogu u signalom putu B limfocita, središnje stanice KLL-a. Osim ciljanog djelovanja, koje sa sobom donosi bolje podnošenje terapije s manje nuspojava, ova vrsta liječenja ima i druge prednosti. Lijek se uzima oralno jednom dnevno, što za bolesnika uvelike olakšava liječenje. Sve navedeno dovelo je do velikog napretka u liječenju KLL-a i omogućilo liječenje pacijenata koji nisu kandidati za ili ne podnose kemoterapiju. Ovaj diplomski rad prikazat će iskustvo Zavoda za hematologiju Kliničke bolnice Merkur u liječenju bolesnika s KLL-om ibrutinibom. Retrospektivno su prikupljeni podaci od 58 pacijenata iz BIS-a i dalje obrađeni. Od tih 58 pacijenata njih 41 nastavlja terapiju. Od ostalih 17 šest je pacijenata umrlo, a 11 je prekinulo dobivati terapiju. Od toga devet zbog progresije, a dvoje zbog nuspojava. Naši rezultati pokazali su vjerojatnost preživljenja 67% nakon 30 mjeseci praćenja. Dobiveni rezultati pokazali su da je ibrutinib učinkovita i sigurna terapija u određenoj indikaciji.

Abstract (english)

Chronic lymphocytic leukemia (CLL) is the most common leukemia in the developed world. It is the disease of the adults, which occurs more often in men. The discovery of new drugs that target tumor cells has greatly changed the approach in the treatment of patients with tumors, as well as those with chronic lymphocytic leukemia. One of these drugs is ibrutinib (Imbruvica), the first irreversible blocker of Bruton's tyrosine kinase (BTK) to be discovered. BTK is a molecule that plays a key role in the signaling pathway of B lymphocytes, the central cells of CLL. In addition to targeted action, which brings with it better endurance therapy with fewer side effects, this type of treatment has other benefits. The drug is taken orally once a day, which greatly facilitates treatment for the patient. All of the above has led to great advances in the treatment of CLL and has enabled the treatment of patients who are not candidates for chemotherapy or do not tolerate it. This thesis will present the experience of the Department of Hematology of the Clinical Hospital Merkur in the treatment of patients with CLL with ibrutinib. In retrospect, data from 58 patients form BIS were collected and further processed. Of these 58 patients, 41 continue therapy. Of the other 17, six died and 11 stopped receiving therapy. Of these, nine due to progression and two due to side effects. Our results showed a 67% probability of survival after 30 months of follow-up. The obtained results showed that ibrutinib is an effective and safe therapy in a certain indication.

• Keywords: kronična limfocitna leukemija; ibrutinib; Brutonova tirozin kinaza; kemoterapija
• Keywords (english): Chronic lymphocytic leukemia; ibrutinib; Bruton's tyrosine kinase; chemotherapy
• Language: croatian
• URN:NBN: urn:nbn:hr:105:149326
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-01-04 09:33:13